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Title: | Association of Obstructive Sleep Apnea with Post-Acute Sequelae of SARS-CoV-2 infection (PASC). | Austin Authors: | Quan, Stuart F;Weaver, Matthew D;Czeisler, Mark É;Barger, Laura K;Booker, Lauren A ;Howard, Mark E ;Jackson, Melinda L ;Lane, Rashon I;McDonald, Christine F ;Ridgers, Anna;Robbins, Rebecca;Varma, Prerna;Wiley, Joshua F;Rajaratnam, Shantha M W;Czeisler, Charles A | Affiliation: | Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA.;Division of Sleep Medicine, Harvard Medical School, Boston, MA. Institute for Breathing and Sleep School of Psychological Sciences, Turner Institute for Brain and Mental Health, Monash University, Melbourne, Victoria, Australia.;Institute for Breathing and Sleep, Austin Health, Heidelberg, Victoria, Australia. Department of Medicine, The University of Melbourne, Melbourne, Victoria, Australia.;Department of Respiratory and Sleep Medicine, Austin Health, Heidelberg, Victoria, Australia.;Faculty of Medicine, Monash University, Melbourne Australia. Francis Weld Peabody Society, Harvard Medical School, Boston, MA.;School of Psychological Sciences, Turner Institute for Brain and Mental Health, Monash University, Melbourne, Victoria, Australia.; |
Issue Date: | 31-Dec-2023 | Date: | 2023 | Publication information: | MedRxiv : the Preprint Server for Health Sciences 2023-12-31 | Abstract: | Obstructive sleep apnea (OSA) is associated with COVID-19 infection. Fewer investigations have assessed OSA as a possible risk for the development of Post-Acute Sequelae of SARS-CoV-2 infection (PASC). In a general population, is OSA associated with increased odds of PASC-related symptoms and with an overall definition of PASC? Cross-sectional survey of a general population of 24,803 U.S. adults. COVID-19 infection occurred in 10,324 (41.6%) participants. Prevalence rates for a wide variety of persistent (> 3 months post infection) putative PASC-related physical and mental health symptoms ranged from 6.5% (peripheral edema) to 19.6% (nervous/anxious). In logistic regression models adjusted for demographic, anthropometric, comorbid medical and socioeconomic factors, OSA was associated with all putative PASC-related symptoms with the highest adjusted odds ratios (aOR) being fever (2.053) and nervous/anxious (1.939) respectively. Elastic net regression identified the 13 of 37 symptoms most strongly associated with COVID-19 infection. Four definitions of PASC were developed using these symptoms either weighted equally or proportionally by their regression coefficients. In all 4 logistic regression models using these definitions, OSA was associated with PASC (range of aORs: 1.934-2.071); this association was mitigated in those with treated OSA. In the best fitting overall model requiring ≥3 symptoms, PASC prevalence was 21.9%. In a general population sample, OSA is associated with the development of PASC-related symptoms and a global definition of PASC. A PASC definition requiring the presence of 3 or more symptoms may be useful in identifying cases and for future research. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/34964 | DOI: | 10.1101/2023.12.30.23300666 | ORCID: | 0000-0002-9474-7679 0000-0003-3578-336X 0000-0003-3100-7347 0000-0001-8547-7331 0000-0001-7262-2632 0000-0003-4976-8101 0000-0002-0612-1466 0000-0001-6481-3391 0000-0003-1360-9387 0000-0003-0288-2505 0000-0001-5408-1625 0000-0002-0271-6702 0000-0001-7527-8558 0000-0002-7408-1849 |
Journal: | MedRxiv : the Preprint Server for Health Sciences | PubMed URL: | 38234859 | Type: | Journal Article | Subjects: | COVID-19 Long COVID Obstructive Sleep Apnea PASC Post-Acute Sequelae of SARS-CoV-2 infection |
Appears in Collections: | Journal articles |
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