Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/34964
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Quan, Stuart F | - |
dc.contributor.author | Weaver, Matthew D | - |
dc.contributor.author | Czeisler, Mark É | - |
dc.contributor.author | Barger, Laura K | - |
dc.contributor.author | Booker, Lauren A | - |
dc.contributor.author | Howard, Mark E | - |
dc.contributor.author | Jackson, Melinda L | - |
dc.contributor.author | Lane, Rashon I | - |
dc.contributor.author | McDonald, Christine F | - |
dc.contributor.author | Ridgers, Anna | - |
dc.contributor.author | Robbins, Rebecca | - |
dc.contributor.author | Varma, Prerna | - |
dc.contributor.author | Wiley, Joshua F | - |
dc.contributor.author | Rajaratnam, Shantha M W | - |
dc.contributor.author | Czeisler, Charles A | - |
dc.date | 2023 | - |
dc.date.accessioned | 2024-01-30T23:22:56Z | - |
dc.date.available | 2024-01-30T23:22:56Z | - |
dc.date.issued | 2023-12-31 | - |
dc.identifier.citation | MedRxiv : the Preprint Server for Health Sciences 2023-12-31 | en_US |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/34964 | - |
dc.description.abstract | Obstructive sleep apnea (OSA) is associated with COVID-19 infection. Fewer investigations have assessed OSA as a possible risk for the development of Post-Acute Sequelae of SARS-CoV-2 infection (PASC). In a general population, is OSA associated with increased odds of PASC-related symptoms and with an overall definition of PASC? Cross-sectional survey of a general population of 24,803 U.S. adults. COVID-19 infection occurred in 10,324 (41.6%) participants. Prevalence rates for a wide variety of persistent (> 3 months post infection) putative PASC-related physical and mental health symptoms ranged from 6.5% (peripheral edema) to 19.6% (nervous/anxious). In logistic regression models adjusted for demographic, anthropometric, comorbid medical and socioeconomic factors, OSA was associated with all putative PASC-related symptoms with the highest adjusted odds ratios (aOR) being fever (2.053) and nervous/anxious (1.939) respectively. Elastic net regression identified the 13 of 37 symptoms most strongly associated with COVID-19 infection. Four definitions of PASC were developed using these symptoms either weighted equally or proportionally by their regression coefficients. In all 4 logistic regression models using these definitions, OSA was associated with PASC (range of aORs: 1.934-2.071); this association was mitigated in those with treated OSA. In the best fitting overall model requiring ≥3 symptoms, PASC prevalence was 21.9%. In a general population sample, OSA is associated with the development of PASC-related symptoms and a global definition of PASC. A PASC definition requiring the presence of 3 or more symptoms may be useful in identifying cases and for future research. | en_US |
dc.language.iso | eng | - |
dc.subject | COVID-19 | en_US |
dc.subject | Long COVID | en_US |
dc.subject | Obstructive Sleep Apnea | en_US |
dc.subject | PASC | en_US |
dc.subject | Post-Acute Sequelae of SARS-CoV-2 infection | en_US |
dc.title | Association of Obstructive Sleep Apnea with Post-Acute Sequelae of SARS-CoV-2 infection (PASC). | en_US |
dc.type | Journal Article | en_US |
dc.identifier.journaltitle | MedRxiv : the Preprint Server for Health Sciences | en_US |
dc.identifier.affiliation | Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA.;Division of Sleep Medicine, Harvard Medical School, Boston, MA. | en_US |
dc.identifier.affiliation | Institute for Breathing and Sleep | en_US |
dc.identifier.affiliation | School of Psychological Sciences, Turner Institute for Brain and Mental Health, Monash University, Melbourne, Victoria, Australia.;Institute for Breathing and Sleep, Austin Health, Heidelberg, Victoria, Australia. | en_US |
dc.identifier.affiliation | Department of Medicine, The University of Melbourne, Melbourne, Victoria, Australia.;Department of Respiratory and Sleep Medicine, Austin Health, Heidelberg, Victoria, Australia.;Faculty of Medicine, Monash University, Melbourne Australia. | en_US |
dc.identifier.affiliation | Francis Weld Peabody Society, Harvard Medical School, Boston, MA.;School of Psychological Sciences, Turner Institute for Brain and Mental Health, Monash University, Melbourne, Victoria, Australia.; | en_US |
dc.identifier.doi | 10.1101/2023.12.30.23300666 | en_US |
dc.type.content | Text | en_US |
dc.identifier.orcid | 0000-0002-9474-7679 | en_US |
dc.identifier.orcid | 0000-0003-3578-336X | en_US |
dc.identifier.orcid | 0000-0003-3100-7347 | en_US |
dc.identifier.orcid | 0000-0001-8547-7331 | en_US |
dc.identifier.orcid | 0000-0001-7262-2632 | en_US |
dc.identifier.orcid | 0000-0003-4976-8101 | en_US |
dc.identifier.orcid | 0000-0002-0612-1466 | en_US |
dc.identifier.orcid | 0000-0001-6481-3391 | en_US |
dc.identifier.orcid | 0000-0003-1360-9387 | en_US |
dc.identifier.orcid | 0000-0003-0288-2505 | en_US |
dc.identifier.orcid | 0000-0001-5408-1625 | en_US |
dc.identifier.orcid | 0000-0002-0271-6702 | en_US |
dc.identifier.orcid | 0000-0001-7527-8558 | en_US |
dc.identifier.orcid | 0000-0002-7408-1849 | en_US |
dc.identifier.pubmedid | 38234859 | - |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.openairetype | Journal Article | - |
crisitem.author.dept | Institute for Breathing and Sleep | - |
crisitem.author.dept | Institute for Breathing and Sleep | - |
crisitem.author.dept | Institute for Breathing and Sleep | - |
crisitem.author.dept | Institute for Breathing and Sleep | - |
crisitem.author.dept | Respiratory and Sleep Medicine | - |
Appears in Collections: | Journal articles |
Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.