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https://ahro.austin.org.au/austinjspui/handle/1/33278| Title: | Expression of NEDD4L and ENaC in Urinary Extracellular Vesicles in Pre-eclampsia. | Austin Authors: | Leung, P Y M;Katerelos, M;Choy, S ;Cook, N;Lee, M;Paizis, K;Abboud, A;Manning, J A;Mount, P F;Power, D A | Affiliation: | Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Australia.;Department of Nephrology, Austin Health, Heidelberg, Australia.;Kidney Laboratory, Institute for Breathing and Sleep, Heidelberg, Australia. Nephrology Institute for Breathing and Sleep Department of Obstetrics & Gynaecology, Mercy Hospital for Women, Heidelberg, Australia. Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, Australia. |
Issue Date: | Dec-2023 | Publication information: | Hypertension in Pregnancy 2023-12; 42(1) | Abstract: | To assess changes in expression of renal epithelial sodium channel (ENaC) and NEDD4L, a ubiquitin ligase, in urinary extracellular vesicles (UEV) of pre-eclamptic women compared to normal pregnant controls. Urine was collected from pre-eclamptic women (PE, n = 20) or during normal pregnancy (NP, n = 20). UEV were separated by differential ultracentrifugation. NEDD4L, α-ENaC and γ-ENaC were identified by immunoblotting. There was no difference in the expression of NEDD4L (p = 0.17) and α-ENaC (p = 0.10). PE subjects showed increased expression of γ-ENaC by 6.9-fold compared to NP (p < 0.0001). ENaC expression is upregulated in UEV of pre-eclamptic subjects but was not associated with changes in NEDD4L. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/33278 | DOI: | 10.1080/10641955.2023.2232029 | ORCID: | 0000-0002-3736-0777 |
Journal: | Hypertension in Pregnancy | Start page: | 2232029 | PubMed URL: | 37417251 | ISSN: | 1525-6065 | Type: | Journal Article | Subjects: | NEDD4L Pre-eclampsia epithelial sodium channel ubiquitin ligase urinary extracellular vesicles Epithelial Sodium Channels/metabolism Extracellular Vesicles/metabolism Pre-Eclampsia/metabolism Nedd4 Ubiquitin Protein Ligases/genetics |
| Appears in Collections: | Journal articles |
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