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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/33278
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dc.contributor.authorLeung, P Y M-
dc.contributor.authorKaterelos, M-
dc.contributor.authorChoy, S-
dc.contributor.authorCook, N-
dc.contributor.authorLee, M-
dc.contributor.authorPaizis, K-
dc.contributor.authorAbboud, A-
dc.contributor.authorManning, J A-
dc.contributor.authorMount, P F-
dc.contributor.authorPower, D A-
dc.date.accessioned2023-07-14T02:52:22Z-
dc.date.available2023-07-14T02:52:22Z-
dc.date.issued2023-12-
dc.identifier.citationHypertension in Pregnancy 2023-12; 42(1)en_US
dc.identifier.issn1525-6065-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/33278-
dc.description.abstractTo assess changes in expression of renal epithelial sodium channel (ENaC) and NEDD4L, a ubiquitin ligase, in urinary extracellular vesicles (UEV) of pre-eclamptic women compared to normal pregnant controls. Urine was collected from pre-eclamptic women (PE, n = 20) or during normal pregnancy (NP, n = 20). UEV were separated by differential ultracentrifugation. NEDD4L, α-ENaC and γ-ENaC were identified by immunoblotting. There was no difference in the expression of NEDD4L (p = 0.17) and α-ENaC (p = 0.10). PE subjects showed increased expression of γ-ENaC by 6.9-fold compared to NP (p < 0.0001). ENaC expression is upregulated in UEV of pre-eclamptic subjects but was not associated with changes in NEDD4L.en_US
dc.language.isoeng-
dc.subjectNEDD4Len_US
dc.subjectPre-eclampsiaen_US
dc.subjectepithelial sodium channelen_US
dc.subjectubiquitin ligaseen_US
dc.subjecturinary extracellular vesiclesen_US
dc.titleExpression of NEDD4L and ENaC in Urinary Extracellular Vesicles in Pre-eclampsia.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleHypertension in Pregnancyen_US
dc.identifier.affiliationFaculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Australia.;Department of Nephrology, Austin Health, Heidelberg, Australia.;Kidney Laboratory, Institute for Breathing and Sleep, Heidelberg, Australia.en_US
dc.identifier.affiliationNephrologyen_US
dc.identifier.affiliationInstitute for Breathing and Sleepen_US
dc.identifier.affiliationDepartment of Obstetrics & Gynaecology, Mercy Hospital for Women, Heidelberg, Australia.en_US
dc.identifier.affiliationCentre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, Australia.en_US
dc.identifier.doi10.1080/10641955.2023.2232029en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0002-3736-0777en_US
dc.identifier.pubmedid37417251-
dc.description.volume42-
dc.description.issue1-
dc.description.startpage2232029-
dc.subject.meshtermssecondaryEpithelial Sodium Channels/metabolism-
dc.subject.meshtermssecondaryExtracellular Vesicles/metabolism-
dc.subject.meshtermssecondaryPre-Eclampsia/metabolism-
dc.subject.meshtermssecondaryNedd4 Ubiquitin Protein Ligases/genetics-
local.name.researcherChoy, Kay T
item.languageiso639-1en-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptSurgery-
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