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https://ahro.austin.org.au/austinjspui/handle/1/21956| Title: | Hydrocortisone Compared with Placebo in Patients with Septic Shock Satisfying the Sepsis-3 Diagnostic Criteria and APROCCHSS Study Inclusion Criteria: A Post Hoc Analysis of the ADRENAL Trial. | Austin Authors: | Venkatesh, Balasubramanian;Finfer, Simon;Cohen, Jeremy;Rajbhandari, Dorrilyn;Arabi, Yaseen;Bellomo, Rinaldo ;Billot, Laurent;Glass, Parisa;Joyce, Christopher;Li, Qiang;McArthur, Colin;Perner, Anders;Rhodes, Andrew;Thompson, Kelly;Webb, Steve;Myburgh, John | Affiliation: | St. George Hospital, University of New South Wales, Sydney, New South Wales Royal Perth Hospital, Perth, Western Australia, Australia University of Western Australia, School of Medicine and Pharmacology, Perth, Western Australia George Institute for Global Health, Sydney, New South Wales, Australia Princess Alexandra Hospital, University of Queensland, Brisbane, Queensland, Australia Wesley Hospital, Brisbane, Queensland, Australia University of New South Wales, Sydney, New South Wales, Australia Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia Royal North Shore Hospital, Sydney, New South Wales, Australia Royal Brisbane and Women's Hospital, University of Queensland, Brisbane, Queensland, Australia King Abdulaziz Medical City, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia Austin Health, Heidelberg, Victoria, Australia the Department of Critical Care Medicine, Auckland City Hospital, Auckland, New Zealand Rigshospitalet, Copenhagen, Denmark St. George's Hospital, London, United Kingdom |
Issue Date: | Dec-2019 | Date: | 2019-10-16 | Publication information: | Anesthesiology 2019; 13(6): 1292-1300 | Abstract: | Definitions and management strategies for septic shock continue to be updated as defined in Sepsis-2, Sepsis-3, and other guidelinesRecent randomized controlled trials of corticosteroids in septic shock report different treatment effects on 90-day mortality but use different inclusion criteria WHAT THIS ARTICLE TELLS US THAT IS NEW: In a post hoc analysis of the Adjunctive Glucocorticoid Therapy in Patients with Septic Shock (ADRENAL) trial, in participants who fulfilled either the Sepsis-3 or -2 inclusion criteria or those with severe septic shock, a continuous infusion of hydrocortisone did not result in a lower 90-day mortality than placebo BACKGROUND | URI: | https://ahro.austin.org.au/austinjspui/handle/1/21956 | DOI: | 10.1097/ALN.0000000000002955 | ORCID: | 0000-0002-1650-8939 | Journal: | Anesthesiology | PubMed URL: | 31651531 | Type: | Journal Article |
| Appears in Collections: | Journal articles |
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