Hydrocortisone Compared with Placebo in Patients with Septic Shock Satisfying the Sepsis-3 Diagnostic Criteria and APROCCHSS Study Inclusion Criteria: A Post Hoc Analysis of the ADRENAL Trial.

Abstract

Definitions and management strategies for septic shock continue to be updated as defined in Sepsis-2, Sepsis-3, and other guidelinesRecent randomized controlled trials of corticosteroids in septic shock report different treatment effects on 90-day mortality but use different inclusion criteria WHAT THIS ARTICLE TELLS US THAT IS NEW: In a post hoc analysis of the Adjunctive Glucocorticoid Therapy in Patients with Septic Shock (ADRENAL) trial, in participants who fulfilled either the Sepsis-3 or -2 inclusion criteria or those with severe septic shock, a continuous infusion of hydrocortisone did not result in a lower 90-day mortality than placebo BACKGROUND