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https://ahro.austin.org.au/austinjspui/handle/1/20197| Title: | TERT gene: its function and dysregulation in cancer. | Austin Authors: | Colebatch, Andrew J;Dobrovic, Alexander ;Cooper, Wendy A | Affiliation: | Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australia Department of Surgery, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia Translational Genomics and Epigenomics Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia School of Cancer Medicine and Molecular Cancer Prevention Program, La Trobe University, Melbourne, Victoria, Australia Department of Clinical Pathology, The University of Melbourne, Parkville, Victoria, Australia Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australia Sydney Medical School, The University of Sydney, Camperdown, New South Wales, Australia School of Medicine, Western Sydney University, Sydney, New South Wales, Australia |
Issue Date: | Apr-2019 | Date: | 2019-01-29 | Publication information: | Journal of clinical pathology 2019; 72(4): 281-284 | Abstract: | In this review, we summarise the function and structure of telomerase reverse transcriptase (TERT) in humans, including its regulation. The dysregulation of telomerase through TERT promoter mutations across a range of cancers is discussed. The molecular mechanism activated by TERT promoter mutations is outlined. Finally, the timing of TERT promoter mutations during carcinogenesis is reviewed in the context of their potential utility as clinical biomarkers of malignant transformation. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/20197 | DOI: | 10.1136/jclinpath-2018-205653 | ORCID: | 0000-0001-5418-4229 0000-0003-3414-112X |
Journal: | Journal of clinical pathology | PubMed URL: | 30696697 | Type: | Journal Article | Subjects: | cancer cancer genetics cancer research |
| Appears in Collections: | Journal articles |
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