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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/20197
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dc.contributor.authorColebatch, Andrew J-
dc.contributor.authorDobrovic, Alexander-
dc.contributor.authorCooper, Wendy A-
dc.date2019-01-29-
dc.date.accessioned2019-02-04T23:34:05Z-
dc.date.available2019-02-04T23:34:05Z-
dc.date.issued2019-04-
dc.identifier.citationJournal of clinical pathology 2019; 72(4): 281-284-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/20197-
dc.description.abstractIn this review, we summarise the function and structure of telomerase reverse transcriptase (TERT) in humans, including its regulation. The dysregulation of telomerase through TERT promoter mutations across a range of cancers is discussed. The molecular mechanism activated by TERT promoter mutations is outlined. Finally, the timing of TERT promoter mutations during carcinogenesis is reviewed in the context of their potential utility as clinical biomarkers of malignant transformation.-
dc.language.isoeng-
dc.subjectcancer-
dc.subjectcancer genetics-
dc.subjectcancer research-
dc.titleTERT gene: its function and dysregulation in cancer.-
dc.typeJournal Article-
dc.identifier.journaltitleJournal of clinical pathology-
dc.identifier.affiliationTissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australia-
dc.identifier.affiliationDepartment of Surgery, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationTranslational Genomics and Epigenomics Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationSchool of Cancer Medicine and Molecular Cancer Prevention Program, La Trobe University, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Clinical Pathology, The University of Melbourne, Parkville, Victoria, Australiaen
dc.identifier.affiliationTissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australiaen
dc.identifier.affiliationSydney Medical School, The University of Sydney, Camperdown, New South Wales, Australiaen
dc.identifier.affiliationSchool of Medicine, Western Sydney University, Sydney, New South Wales, Australiaen
dc.identifier.doi10.1136/jclinpath-2018-205653-
dc.identifier.orcid0000-0001-5418-4229-
dc.identifier.orcid0000-0003-3414-112X-
dc.identifier.pubmedid30696697-
dc.type.austinJournal Article-
local.name.researcherDobrovic, Alexander
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.deptOlivia Newton-John Cancer Research Institute-
crisitem.author.deptSurgery (University of Melbourne)-
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