Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/13539| Title: | Chronic vasopressin antagonism in two-kidney, one-clip renovascular hypertension. | Austin Authors: | Burrell, Louise M ;Risvanis, John;Phillips, P A;Naitoh, M;Johnston, Colin I | Affiliation: | Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Hospital, Victoria, Australia | Issue Date: | 8-Jul-1997 | Publication information: | Clinical and Experimental Hypertension (new York, N.y. : 1993); 19(5-6): 981-91 | Abstract: | The role of vasopressin (AVP) in the maintenance of hypertension in the rat model of two-kidney, one-clip (2K1C) Goldblatt hypertension was assessed using the nonpeptide orally effective V1a receptor antagonist, OPC-21268. Rats were studied eight weeks after surgery when mean arterial pressure (MAP) was significantly increased in 2K1C rats compared to SHAM operated controls (2K1C 139 +/- 6, SHAM 106 +/- 3, P < 0.01). Neither acute (OPC-21268, 30 mg/kg) nor chronic (OPC-21268, 30 mg/kg twice daily) V1a receptor blockade reduced blood pressure in either 2K1C or SHAM rats. The results of binding kinetic studies confirmed that OPC-21268 was effective at its putative site of action, the V1a receptor in both 2K1C and SHAM rats. These results indicate AVP is not involved in the maintenance of blood pressure in the 2K1C model of renovascular hypertension. | Gov't Doc #: | 9247769 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/13539 | Journal: | Clinical and experimental hypertension (New York, N.Y. : 1993) | URL: | https://pubmed.ncbi.nlm.nih.gov/9247769 | Type: | Journal Article | Subjects: | Animals Antidiuretic Hormone Receptor Antagonists Arginine Vasopressin.antagonists & inhibitors.physiology Blood Pressure.drug effects Female Hypertension, Renovascular.drug therapy.metabolism.physiopathology Kinetics Piperidines.metabolism.pharmacology Quinolones.metabolism.pharmacology Rats Rats, Sprague-Dawley Receptors, Vasopressin.metabolism |
| Appears in Collections: | Journal articles |
Show full item record
Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.