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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13539
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dc.contributor.authorBurrell, Louise Men
dc.contributor.authorRisvanis, Johnen
dc.contributor.authorPhillips, P Aen
dc.contributor.authorNaitoh, Men
dc.contributor.authorJohnston, Colin Ien
dc.date.accessioned2015-05-16T03:24:52Z
dc.date.available2015-05-16T03:24:52Z
dc.date.issued1997-07-08en
dc.identifier.citationClinical and Experimental Hypertension (new York, N.y. : 1993); 19(5-6): 981-91en
dc.identifier.govdoc9247769en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/13539en
dc.description.abstractThe role of vasopressin (AVP) in the maintenance of hypertension in the rat model of two-kidney, one-clip (2K1C) Goldblatt hypertension was assessed using the nonpeptide orally effective V1a receptor antagonist, OPC-21268. Rats were studied eight weeks after surgery when mean arterial pressure (MAP) was significantly increased in 2K1C rats compared to SHAM operated controls (2K1C 139 +/- 6, SHAM 106 +/- 3, P < 0.01). Neither acute (OPC-21268, 30 mg/kg) nor chronic (OPC-21268, 30 mg/kg twice daily) V1a receptor blockade reduced blood pressure in either 2K1C or SHAM rats. The results of binding kinetic studies confirmed that OPC-21268 was effective at its putative site of action, the V1a receptor in both 2K1C and SHAM rats. These results indicate AVP is not involved in the maintenance of blood pressure in the 2K1C model of renovascular hypertension.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherAntidiuretic Hormone Receptor Antagonistsen
dc.subject.otherArginine Vasopressin.antagonists & inhibitors.physiologyen
dc.subject.otherBlood Pressure.drug effectsen
dc.subject.otherFemaleen
dc.subject.otherHypertension, Renovascular.drug therapy.metabolism.physiopathologyen
dc.subject.otherKineticsen
dc.subject.otherPiperidines.metabolism.pharmacologyen
dc.subject.otherQuinolones.metabolism.pharmacologyen
dc.subject.otherRatsen
dc.subject.otherRats, Sprague-Dawleyen
dc.subject.otherReceptors, Vasopressin.metabolismen
dc.titleChronic vasopressin antagonism in two-kidney, one-clip renovascular hypertension.en
dc.typeJournal Articleen
dc.identifier.journaltitleClinical and experimental hypertension (New York, N.Y. : 1993)en
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Hospital, Victoria, Australiaen
dc.description.pages981-91en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/9247769en
dc.type.austinJournal Articleen
local.name.researcherBurrell, Louise M
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptCardiology-
crisitem.author.deptGeneral Medicine-
crisitem.author.deptMedicine (University of Melbourne)-
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