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https://ahro.austin.org.au/austinjspui/handle/1/13206| Title: | A stable leukocyte-derived factor inhibits platelet aggregation. | Austin Authors: | Liu, J J;Xie, B;Smith, I L;Johnston, Colin I;Buxton, Brian F | Affiliation: | University of Melbourne, Austin Hospital Department of Cardiac Surgery, Heidelberg, Victoria, Australia | Issue Date: | 15-Jun-1994 | Publication information: | Biochemical and Biophysical Research Communications; 201(2): 878-82 | Abstract: | The effect of human polymorphonuclear leukocyte (PMN)-derived supernatants on platelet aggregation was studied. The results showed that the supernatants produced a concentration-dependent inhibition of the platelet aggregation in response to thrombin. The effect was mainly on the second phase of the aggregation, suggesting that the secretory mechanisms of the platelets are disturbed. The activity of the supernatants was not reduced after treatment with heat (95 degrees C for 30 minutes), extreme pH (pH 12 or pH 2) or protease. In conclusion, human PMNs release a stable non-protein factor that inhibits platelet aggregation. | Gov't Doc #: | 8003026 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/13206 | DOI: | 10.1006/bbrc.1994.1783 | Journal: | Biochemical and biophysical research communications | URL: | https://pubmed.ncbi.nlm.nih.gov/8003026 | Type: | Journal Article | Subjects: | Biological Factors.blood.physiology Blood Platelets.drug effects.physiology Humans In Vitro Techniques Kinetics Neutrophils.physiology Platelet Aggregation.drug effects.physiology Thrombin.pharmacology Tissue Extracts.pharmacology |
| Appears in Collections: | Journal articles |
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