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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13206
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dc.contributor.authorLiu, J Jen
dc.contributor.authorXie, Ben
dc.contributor.authorSmith, I Len
dc.contributor.authorJohnston, Colin Ien
dc.contributor.authorBuxton, Brian Fen
dc.date.accessioned2015-05-16T03:00:19Z
dc.date.available2015-05-16T03:00:19Z
dc.date.issued1994-06-15en
dc.identifier.citationBiochemical and Biophysical Research Communications; 201(2): 878-82en
dc.identifier.govdoc8003026en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/13206en
dc.description.abstractThe effect of human polymorphonuclear leukocyte (PMN)-derived supernatants on platelet aggregation was studied. The results showed that the supernatants produced a concentration-dependent inhibition of the platelet aggregation in response to thrombin. The effect was mainly on the second phase of the aggregation, suggesting that the secretory mechanisms of the platelets are disturbed. The activity of the supernatants was not reduced after treatment with heat (95 degrees C for 30 minutes), extreme pH (pH 12 or pH 2) or protease. In conclusion, human PMNs release a stable non-protein factor that inhibits platelet aggregation.en
dc.language.isoenen
dc.subject.otherBiological Factors.blood.physiologyen
dc.subject.otherBlood Platelets.drug effects.physiologyen
dc.subject.otherHumansen
dc.subject.otherIn Vitro Techniquesen
dc.subject.otherKineticsen
dc.subject.otherNeutrophils.physiologyen
dc.subject.otherPlatelet Aggregation.drug effects.physiologyen
dc.subject.otherThrombin.pharmacologyen
dc.subject.otherTissue Extracts.pharmacologyen
dc.titleA stable leukocyte-derived factor inhibits platelet aggregation.en
dc.typeJournal Articleen
dc.identifier.journaltitleBiochemical and biophysical research communicationsen
dc.identifier.affiliationUniversity of Melbourne, Austin Hospital Department of Cardiac Surgery, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1006/bbrc.1994.1783en
dc.description.pages878-82en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/8003026en
dc.type.austinJournal Articleen
local.name.researcherBuxton, Brian F
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.grantfulltextnone-
item.languageiso639-1en-
crisitem.author.deptCardiac Surgery-
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