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https://ahro.austin.org.au/austinjspui/handle/1/12815| Title: | Streptozotocin-induced diabetes reduces the density of [125I]-endothelin-binding sites in rat cardiac membranes. | Austin Authors: | Nayler, W G;Liu, J J;Panagiotopoulos, Sianna ;Casley, David J | Affiliation: | Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia | Issue Date: | 1-Aug-1989 | Publication information: | British Journal of Pharmacology; 97(4): 993-5 | Abstract: | The effect of acute, streptozotocin-induced diabetes on the affinity (KD), density (Bmax) and selectivity of specific, high affinity binding sites for [125I]-endothelin [( 125I]-ET) in rat cardiac membrane fragments was determined. Three days after a single i.v. bolus dose of streptozotocin (60 mg kg-1), the density of [125I]ET binding sites was reduced (P less than 0.01) without changes in affinity or selectivity. | Gov't Doc #: | 2676060 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/12815 | ORCID: | 0000-0002-0845-0001 | Journal: | British journal of pharmacology | URL: | https://pubmed.ncbi.nlm.nih.gov/2676060 | Type: | Journal Article | Subjects: | Animals Binding Sites Diabetes Mellitus, Experimental.metabolism Endothelins In Vitro Techniques Iodine Radioisotopes.diagnostic use Male Membranes.metabolism Myocardium.metabolism Peptides.metabolism Rats Rats, Inbred Strains |
| Appears in Collections: | Journal articles |
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