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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12815
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dc.contributor.authorNayler, W Gen
dc.contributor.authorLiu, J Jen
dc.contributor.authorPanagiotopoulos, Siannaen
dc.contributor.authorCasley, David Jen
dc.date.accessioned2015-05-16T02:33:34Z-
dc.date.available2015-05-16T02:33:34Z-
dc.date.issued1989-08-01en
dc.identifier.citationBritish Journal of Pharmacology; 97(4): 993-5en
dc.identifier.govdoc2676060en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12815en
dc.description.abstractThe effect of acute, streptozotocin-induced diabetes on the affinity (KD), density (Bmax) and selectivity of specific, high affinity binding sites for [125I]-endothelin [( 125I]-ET) in rat cardiac membrane fragments was determined. Three days after a single i.v. bolus dose of streptozotocin (60 mg kg-1), the density of [125I]ET binding sites was reduced (P less than 0.01) without changes in affinity or selectivity.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherBinding Sitesen
dc.subject.otherDiabetes Mellitus, Experimental.metabolismen
dc.subject.otherEndothelinsen
dc.subject.otherIn Vitro Techniquesen
dc.subject.otherIodine Radioisotopes.diagnostic useen
dc.subject.otherMaleen
dc.subject.otherMembranes.metabolismen
dc.subject.otherMyocardium.metabolismen
dc.subject.otherPeptides.metabolismen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred Strainsen
dc.titleStreptozotocin-induced diabetes reduces the density of [125I]-endothelin-binding sites in rat cardiac membranes.en
dc.typeJournal Articleen
dc.identifier.journaltitleBritish journal of pharmacologyen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages993-5en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/2676060en
dc.identifier.orcid0000-0002-0845-0001-
dc.type.austinJournal Articleen
local.name.researcherPanagiotopoulos, Sianna
item.grantfulltextnone-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.deptOffice for Research-
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