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https://ahro.austin.org.au/austinjspui/handle/1/12522| Title: | Enalapril retards glomerular basement membrane thickening and albuminuria in the diabetic rat. | Austin Authors: | Cooper, Mark E;Allen, Terri J;Macmillan, P A;Clarke, B E;Jerums, George ;Doyle, A E | Affiliation: | Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia | Issue Date: | 1-May-1989 | Publication information: | Diabetologia; 32(5): 326-8 | Abstract: | This study has evaluated the effects of the angiotensin converting enzyme inhibitor Enalapril on glomerular ultrastructure and albuminuria in normotensive and hypertensive diabetic rats. Streptozotocin-diabetes was induced in Wistar Kyoto and spontaneously hypertensive rats. Enalapril was administered in drinking water in diabetic normotensive, control hypertensive and diabetic hypertensive rats. Enalapril therapy prevented an increase in glomerular basement membrane thickness in diabetic normotensive, control hypertensive and diabetic hypertensive rats without any significant effect on fractional mesangial volume. Enalapril decreased albuminuria in diabetic normotensive, control hypertensive and diabetic hypertensive rats. Thus, enalapril retards the development of glomerular basement membrane thickening and albuminuria in the rat, in the presence or absence of hypertension. | Gov't Doc #: | 2546846 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/12522 | Journal: | Diabetologia | URL: | https://pubmed.ncbi.nlm.nih.gov/2546846 | Type: | Journal Article | Subjects: | Albuminuria Animals Basement Membrane.drug effects.pathology.ultrastructure Blood Pressure Diabetes Mellitus, Experimental.drug therapy.pathology Diabetic Nephropathies.pathology.prevention & control Enalapril.therapeutic use Kidney Glomerulus.drug effects.pathology.ultrastructure Male Rats Rats, Inbred SHR Rats, Inbred WKY Reference Values |
| Appears in Collections: | Journal articles |
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