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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12522
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dc.contributor.authorCooper, Mark Een
dc.contributor.authorAllen, Terri Jen
dc.contributor.authorMacmillan, P Aen
dc.contributor.authorClarke, B Een
dc.contributor.authorJerums, Georgeen
dc.contributor.authorDoyle, A Een
dc.date.accessioned2015-05-16T02:13:50Z
dc.date.available2015-05-16T02:13:50Z
dc.date.issued1989-05-01en
dc.identifier.citationDiabetologia; 32(5): 326-8en
dc.identifier.govdoc2546846en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12522en
dc.description.abstractThis study has evaluated the effects of the angiotensin converting enzyme inhibitor Enalapril on glomerular ultrastructure and albuminuria in normotensive and hypertensive diabetic rats. Streptozotocin-diabetes was induced in Wistar Kyoto and spontaneously hypertensive rats. Enalapril was administered in drinking water in diabetic normotensive, control hypertensive and diabetic hypertensive rats. Enalapril therapy prevented an increase in glomerular basement membrane thickness in diabetic normotensive, control hypertensive and diabetic hypertensive rats without any significant effect on fractional mesangial volume. Enalapril decreased albuminuria in diabetic normotensive, control hypertensive and diabetic hypertensive rats. Thus, enalapril retards the development of glomerular basement membrane thickening and albuminuria in the rat, in the presence or absence of hypertension.en
dc.language.isoenen
dc.subject.otherAlbuminuriaen
dc.subject.otherAnimalsen
dc.subject.otherBasement Membrane.drug effects.pathology.ultrastructureen
dc.subject.otherBlood Pressureen
dc.subject.otherDiabetes Mellitus, Experimental.drug therapy.pathologyen
dc.subject.otherDiabetic Nephropathies.pathology.prevention & controlen
dc.subject.otherEnalapril.therapeutic useen
dc.subject.otherKidney Glomerulus.drug effects.pathology.ultrastructureen
dc.subject.otherMaleen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred SHRen
dc.subject.otherRats, Inbred WKYen
dc.subject.otherReference Valuesen
dc.titleEnalapril retards glomerular basement membrane thickening and albuminuria in the diabetic rat.en
dc.typeJournal Articleen
dc.identifier.journaltitleDiabetologiaen
dc.identifier.affiliationDepartment of Medicine, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages326-8en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/2546846en
dc.type.austinJournal Articleen
local.name.researcherJerums, George
item.grantfulltextnone-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.deptEndocrinology-
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