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Title: | Impact of 2-deoxy-2[F-18]fluoro-D-glucose Positron Emission Tomography on the management of patients with advanced melanoma. | Austin Authors: | Harris, Marion T;Berlangieri, Salvatore U ;Cebon, Jonathan S ;Davis, Ian D;Scott, Andrew M | Affiliation: | Centre for Positron Emission Tomography, Austin Hospital, Heidelberg, Victoria, Australia | Issue Date: | 8-Jul-2005 | Publication information: | Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging; 7(4): 304-8 | Abstract: | Accurate staging of patients with melanoma is vital to guide appropriate treatment. 2-Deoxy-2-[F-18]fluoro-D-glucose (FDG)-positron emission tomography (PET) has been reported to be a sensitive and specific technique for the staging of advanced melanoma, however, few studies provide information regarding its impact on patient management.We retrospectively reviewed the FDG-PET scan results of 92 patients with melanoma who had 126 scans performed over a six-year period. These patients were seen at the specialist melanoma clinic at our Institution, and 84 patients (92%) had stage III or IV disease. FDG-PET scan results were correlated with computed tomography (CT) scans and other imaging when available, and with clinical follow-up of a minimum of three to six months. The impact of FDG-PET scans on patient management was also assessed.On a lesion-by-lesion analysis, FDG-PET had a sensitivity of 92%, a specificity of 88%, and an accuracy of 91%. FDG-PET correctly affected the clinical decision-making process in 40 of 126 patient studies (32%), particularly assisting in the selection of patients for surgery.FDG-PET has an important role in guiding the management of patients with advanced melanoma, particularly when surgery is contemplated. | Gov't Doc #: | 16041590 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/9967 | DOI: | 10.1007/s11307-005-0002-7 | Journal: | Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging | URL: | https://pubmed.ncbi.nlm.nih.gov/16041590 | Type: | Journal Article | Subjects: | Adult Aged False Negative Reactions False Positive Reactions Female Fluorodeoxyglucose F18.metabolism Humans Lung.pathology Male Melanoma.diagnosis.pathology.therapy Middle Aged Neoplasm Staging Positron-Emission Tomography.methods Ribs.pathology Treatment Outcome |
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