Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9868
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dc.contributor.authorO'Donoghue, Fergal Jen
dc.contributor.authorBriellmann, Regula Sen
dc.contributor.authorRochford, Peter Den
dc.contributor.authorAbbott, David Fen
dc.contributor.authorPell, Gaby Sen
dc.contributor.authorChan, Chow Huat Patricken
dc.contributor.authorTarquinio, Natalieen
dc.contributor.authorJackson, Graeme Den
dc.contributor.authorPierce, Robert Jen
dc.date.accessioned2015-05-15T23:08:13Z
dc.date.available2015-05-15T23:08:13Z
dc.date.issued2005-02-01en
dc.identifier.citationAmerican Journal of Respiratory and Critical Care Medicine 2005; 171(10): 1185-90en
dc.identifier.govdoc15699018en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9868en
dc.description.abstractObstructive sleep apnea is associated with abnormalities in neuropsychologic function, and defects in respiratory control may contribute to pathogenesis. Abnormalities may be reflected in structural brain changes. Twenty-seven male untreated patients with severe sleep apnea without comorbidities, and 24 age-matched control subjects, had T1-weighted brain imaging in a high-resolution magnetic resonance scanner. Twenty-three patients with sleep apnea had repeat imaging after 6 months of continuous positive airways pressure treatment. No areas of gray matter volume change were found in patients using an optimized voxel-based morphometry technique, at p < 0.05 adjusted for multiple comparisons (despite the method being sensitive to changes in gray matter fraction of 0.17 or less in all voxels). Furthermore, no differences were seen in bilateral hippocampal, temporal lobe, or whole brain volumes, assessed by manual tracing of anatomical borders. No longitudinal changes were seen in gray matter density or regional volumes after treatment, but whole brain volume decreased slightly. We have found no gray matter volume deficits nor focal structural changes in severe obstructive sleep apnea. Whole brain volume decreases without focal changes after 6 months of continuous positive airways pressure treatment.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherBrain Diseases.etiology.pathologyen
dc.subject.otherContinuous Positive Airway Pressureen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherOrgan Sizeen
dc.subject.otherSensitivity and Specificityen
dc.subject.otherSleep Apnea, Obstructive.complications.therapyen
dc.subject.otherTelencephalon.pathologyen
dc.titleCerebral structural changes in severe obstructive sleep apnea.en
dc.typeJournal Articleen
dc.identifier.journaltitleAmerican Journal of Respiratory and Critical Care Medicineen
dc.identifier.affiliationInstitute for Breathing and Sleep, Austin Health, Heidelberg 3081 West, Australiaen
dc.identifier.affiliationfandtod@bigpond.net.auen
dc.identifier.doi10.1164/rccm.200406-738OCen
dc.description.pages1185-90en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/15699018en
dc.type.austinJournal Articleen
local.name.researcherAbbott, David F
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptRespiratory and Sleep Medicine-
crisitem.author.deptInstitute for Breathing and Sleep-
crisitem.author.deptRespiratory and Sleep Medicine-
crisitem.author.deptInstitute for Breathing and Sleep-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptNeurology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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