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https://ahro.austin.org.au/austinjspui/handle/1/9781
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tan, Han Khim | en |
dc.contributor.author | Uchino, Shigehiko | en |
dc.contributor.author | Bellomo, Rinaldo | en |
dc.date.accessioned | 2015-05-15T22:59:57Z | |
dc.date.available | 2015-05-15T22:59:57Z | |
dc.date.issued | 2004-03-01 | en |
dc.identifier.citation | Renal Failure; 26(2): 149-53 | en |
dc.identifier.govdoc | 15287198 | en |
dc.identifier.other | PUBMED | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/9781 | en |
dc.description.abstract | To compare the effect of lactate vs. bicarbonate-buffered replacement fluids on electrolyte mass balance during isovolemic continuous veno-venous hemofiltration (CVVH).Randomized controlled study with double cross over.Intensive care unit of a tertiary university hospital.Eight patients with acute renal failure (ARF).Isovolemic CVVH (2L/hr of replacement fluid) was performed in random order with either bicarbonate or lactate-buffered replacement fluid delivered pre-filter.Sodium, potassium, chloride, magnesium, and phosphate, were measured in each sample. There was a mass gain of sodium, which was similar under both conditions (bicarbonate: 23.3+/-4.9 mmol/hr, lactate: 22.7+/-3.5 mmol/hr). Mass chloride gains occurred with bicarbonate-buffered replacement fluid only (12.8+/-5.3 mmol/hr), while there was an overall net loss of chloride with lactate fluids (-2.5+/-5.2 mmol/hr), resulting in a significant difference in chloride mass balance (p<0.0001). Magnesium mass balance was negative with bicarbonate buffer only (-0.6+/-0.2 mmol/hr) and also differed significantly from that obtained with lactate fluids (-0.1+/-0.2 mmol/hr, p<0.0001). Phosphate losses (bicarbonate: -1.7+/-0.7 mmol/hr, lactate: -1.7+/-0.5 mmol/hr) were equivalent with both buffers. Potassium mass balance was neutral.Mass balance during isovolemic CVVH is significantly affected by the type of replacement fluid administered prefilter. Isovolemic CVVH is not isonatremic and the use of bicarbonate-buffered fluid results in a significant accumulation of chloride and a loss of magnesium. | en |
dc.language.iso | en | en |
dc.subject.other | Acute Kidney Injury.diagnosis.mortality.therapy | en |
dc.subject.other | Adult | en |
dc.subject.other | Aged | en |
dc.subject.other | Bicarbonates.therapeutic use | en |
dc.subject.other | Buffers | en |
dc.subject.other | Cross-Over Studies | en |
dc.subject.other | Emergency Service, Hospital | en |
dc.subject.other | Female | en |
dc.subject.other | Follow-Up Studies | en |
dc.subject.other | Hemodialysis Solutions | en |
dc.subject.other | Hemofiltration.methods | en |
dc.subject.other | Humans | en |
dc.subject.other | Male | en |
dc.subject.other | Middle Aged | en |
dc.subject.other | Probability | en |
dc.subject.other | Risk Assessment | en |
dc.subject.other | Sodium Lactate.therapeutic use | en |
dc.subject.other | Statistics, Nonparametric | en |
dc.subject.other | Survival Rate | en |
dc.subject.other | Treatment Outcome | en |
dc.subject.other | Water-Electrolyte Balance.physiology | en |
dc.title | Electrolyte mass balance during CVVH: lactate vs. bicarbonate-buffered replacement fluids. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Renal failure | en |
dc.identifier.affiliation | Department of Intensive Care and Surgery, Austin Hospital, Melbourne, Australia | en |
dc.description.pages | 149-53 | en |
dc.relation.url | https://pubmed.ncbi.nlm.nih.gov/15287198 | en |
dc.type.austin | Journal Article | en |
local.name.researcher | Bellomo, Rinaldo | |
item.openairetype | Journal Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Intensive Care | - |
crisitem.author.dept | Data Analytics Research and Evaluation (DARE) Centre | - |
Appears in Collections: | Journal articles |
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