Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/9472
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Uchino, Shigehiko | en |
dc.contributor.author | Cole, Louise | en |
dc.contributor.author | Morimatsu, Hiroshi | en |
dc.contributor.author | Goldsmith, Donna | en |
dc.contributor.author | Bellomo, Rinaldo | en |
dc.date.accessioned | 2015-05-15T22:34:48Z | |
dc.date.available | 2015-05-15T22:34:48Z | |
dc.date.issued | 2002-11-01 | en |
dc.identifier.citation | Intensive Care Medicine; 28(11): 1664-7 | en |
dc.identifier.govdoc | 12583375 | en |
dc.identifier.other | PUBMED | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/9472 | en |
dc.description.abstract | To measure the sieving coefficient (SC) and clearance of vancomycin during high-volume haemofiltration (HVHF) and to evaluate the impact of different pre-dilution regimens on these variables.Prospective interventional study in the intensive care unit in a tertiary university hospital.Seven patients with septic shock and multi-organ dysfunction.HVHF (6 l/h fluid exchange) was performed in septic shock patients using variable proportions of their replacement fluid in pre- and post-dilution mode.Pre-filter, post-filter and ultrafiltrate vancomycin concentrations were measured simultaneously, and SC and clearance calculated. The measurements were repeated following each change in the proportion of pre-dilution fluid. SC steadily decreased as the proportion of pre-dilution decreased, changing from 0.76 in pure pre-dilution to 0.57 in pure post-dilution (p=0.0004). Clearance, however, increased with decreasing pre-dilution fluid rate, from 53.9 ml/min at pure pre-dilution to 67.2 ml/min at 2 l/h pre-dilution with 4 l/h post-dilution.HVHF achieves high vancomycin clearances, which despite some deterioration in SC increase with the proportion of replacement fluid given post-filter. Clinicians applying HVHF need to be aware of such clearances to avoid inadequate vancomycin dosing and to adjust therapy according to variations in HVHF technique. | en |
dc.language.iso | en | en |
dc.subject.other | Acute Kidney Injury.etiology.therapy | en |
dc.subject.other | Aged | en |
dc.subject.other | Anti-Bacterial Agents.pharmacokinetics | en |
dc.subject.other | Critical Illness | en |
dc.subject.other | Cross-Over Studies | en |
dc.subject.other | Female | en |
dc.subject.other | Hemofiltration.methods | en |
dc.subject.other | Humans | en |
dc.subject.other | Male | en |
dc.subject.other | Middle Aged | en |
dc.subject.other | Multiple Organ Failure.complications.therapy | en |
dc.subject.other | Prospective Studies | en |
dc.subject.other | Shock, Septic.complications.therapy | en |
dc.subject.other | Vancomycin.pharmacokinetics | en |
dc.title | Clearance of vancomycin during high-volume haemofiltration: impact of pre-dilution. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Intensive Care Medicine | en |
dc.identifier.affiliation | Department of Intensive Care and Medicine, University of Melbourne, and Austin & Repatriation Medical Centre Melbourne, Heidelberg, Victoria, Australia | en |
dc.description.pages | 1664-7 | en |
dc.relation.url | https://pubmed.ncbi.nlm.nih.gov/12583375 | en |
dc.type.austin | Journal Article | en |
local.name.researcher | Bellomo, Rinaldo | |
item.openairetype | Journal Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Intensive Care | - |
crisitem.author.dept | Data Analytics Research and Evaluation (DARE) Centre | - |
Appears in Collections: | Journal articles |
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