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https://ahro.austin.org.au/austinjspui/handle/1/9357| Title: | Evidence for cardioprotective, renoprotective, and vasculoprotective effects of vasopeptidase inhibitors in disease. | Austin Authors: | Kubota, E;Dean, Rachael G;Hubner, R A;Balding, Leanne C;Johnston, Colin I;Burrell, Louise M | Affiliation: | Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Studley Road, Heidelberg 3084, Victoria, Australia | Issue Date: | 1-Dec-2001 | Publication information: | Current Hypertension Reports; 3 Suppl 2(): S31-3 | Abstract: | In both the natriuretic peptide and renin-angiotensin systems, peptidases play an important role in the inactivation or activation of the system. Angiotensin-converting enzyme is responsible for the conversion of angiotensin I to angiotensin II, while neutral endopeptidase is one of the pathways involved in the degradation of the natriuretic peptides. The vasopeptidase inhibitors, which simultaneously inhibit neutral endopeptidase and angiotensin-converting enzyme, appear to offer distinct therapeutic advantages in treating hypertension, heart failure, and endothelial dysfunction. | Gov't Doc #: | 11716804 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/9357 | Journal: | Current hypertension reports | URL: | https://pubmed.ncbi.nlm.nih.gov/11716804 | Type: | Journal Article | Subjects: | Angiotensin-Converting Enzyme Inhibitors.pharmacology Cardiotonic Agents.pharmacology Endothelium, Vascular.drug effects Heart.drug effects Heart Failure.drug therapy Humans Hypertension.drug therapy Kidney.drug effects Kidney Failure, Chronic.drug therapy.etiology Neprilysin.antagonists & inhibitors Renin-Angiotensin System.drug effects |
| Appears in Collections: | Journal articles |
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