Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/35615
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dc.contributor.authorCaragata, Rebecca-
dc.contributor.authorJohnston, Samuel A-
dc.contributor.authorChan, Jian Wen-
dc.contributor.authorStarkey, Graham M-
dc.contributor.authorBellomo, Rinaldo-
dc.date2024-
dc.date.accessioned2024-12-11T22:21:17Z-
dc.date.available2024-12-11T22:21:17Z-
dc.date.issued2024-12-01-
dc.identifier.citationCritical Care Medicine 2024-12-01; 52(12)en_US
dc.identifier.issn1530-0293-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/35615-
dc.description.abstractTo evaluate and synthesize the existing evidence for the association of angiotensin-II with thromboembolic events. PubMed, Scopus, and CENTRAL databases. This systematic review included randomized trials and comparative observational studies that reported on the occurrence of venous and/or arterial thromboembolic events in adult patients receiving treatment for shock with angiotensin-II vs. a comparator. A total of 1689 records were screened by two independent investigators. Seven studies were deemed eligible for inclusion, encompassing 1461 patients. This included two randomized controlled trials and five nonrandomized studies of intervention. Data were extracted independently and in duplicate. Risk of bias assessments were performed using the Risk of Bias 2 and Risk Of Bias In Nonrandomized Studies of Interventions tools. The included studies reported on a variety of individual and composite thromboembolic events as exploratory endpoints. Overall, they demonstrated an elevated risk of bias, predominantly related to confounding, measurement of outcomes and selection of reported results, which precluded quantitative synthesis. Within these limitations, we found that thromboembolic event rates were similar between the angiotensin-II and comparator groups. Venous thromboembolic events were described in 8.8% of patients receiving angiotensin-II and 9.4% of controls, while arterial thromboembolic events were reported in 11.3% and 12.7%, respectively. Total event rates were broadly comparable when utilizing data derived from the primary publications and when adjusted for the U.S. Food and Drug Administration account of trial data. Published evidence does not currently support or refute an association between angiotensin-II and an increased risk of venous or arterial thromboembolic events. Given the limited quality of available data, future studies should explicitly define diagnostic and reporting criteria for such events.en_US
dc.language.isoeng-
dc.titleAngiotensin-II and Thromboembolic Events: A Systematic Review.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleCritical Care Medicineen_US
dc.identifier.affiliationAnaesthesiaen_US
dc.identifier.affiliationIntensive Careen_US
dc.identifier.affiliationThe Surgery Centreen_US
dc.identifier.affiliationDepartment of Critical Care, School of Medicine, University of Melbourne, Melbourne, VIC, Australia.;Department of Intensive Care, Austin Health, Melbourne, VIC, Australia.;Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia.;Data Analytics Research and Evaluation, Austin Hospital, Melbourne, VIC, Australia.;Department of Intensive Care, Royal Melbourne Hospital, Melbourne, VIC, Australia.en_US
dc.identifier.affiliationVictorian Liver Transplant Uniten_US
dc.identifier.doi10.1097/CCM.0000000000006433en_US
dc.type.contentTexten_US
dc.identifier.pubmedid39637259-
dc.description.volume52-
dc.description.issue12-
dc.description.startpage1894-
dc.description.endpage1905-
dc.subject.meshtermssecondaryThromboembolism/epidemiology-
dc.subject.meshtermssecondaryThromboembolism/etiology-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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