Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/35327
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dc.contributor.authorAng, Hui Li-
dc.contributor.authorSchulte, Max-
dc.contributor.authorChan, Roseanne Kimberley-
dc.contributor.authorTan, Hann Hsiang-
dc.contributor.authorHarrison, Amelia-
dc.contributor.authorRyerson, Christopher J-
dc.contributor.authorKhor, Yet Hong-
dc.date2024-
dc.date.accessioned2024-06-21T06:19:17Z-
dc.date.available2024-06-21T06:19:17Z-
dc.date.issued2024-10-
dc.identifier.citationChest 2024-10; 166(4)en_US
dc.identifier.issn1931-3543-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/35327-
dc.description.abstractPulmonary hypertension (PH) is a key complication in interstitial lung disease (ILD), with recent therapeutic advances. What are the diagnostic evaluation, epidemiology, associated factors, prognostic significance, and outcome measures in interventional trials for PH in patients with ILD in current literature? Ovid MEDLINE, Embase, and CENTRAL databases were searched for original research evaluating PH in participants with ILD of any aetiology. The definition of PH was based on the investigators' criteria. 302 studies were included, with varying diagnostic evaluation used to define PH. Commonly used diagnostic tests were right heart catheterisation (RHC) (56%) and transthoracic echocardiogram (TTE) (50%). The pooled prevalence for PH in general ILD populations was 36% (95%CI 30-42%) using RHC, and 34% (95%CI 29-38%) using TTE. Lower diffusion capacity for carbon monoxide, worse oxygenation status, reduced exercise capacity, increased pulmonary artery to aorta ratio and pulmonary artery diameter, and elevated serum brain natriuretic peptide were consistently associated with the presence of PH in at least 60% of reported studies. The presence of PH was associated with increased symptom burden and worse prognosis. Outcome measures in interventional trials of PH in ILD focused on changes in pulmonary vascular haemodynamic and 6-minute walk distance. PH is a common complication in ILD with significant health impacts. A standardised definition with prospective evaluation of risk-stratified assessments for PH using identified associated risk factors is warranted. Our findings provide an evidence base for validation as surrogate endpoints in future PH interventional trials in ILD.en_US
dc.language.isoeng-
dc.subjectinterstitial lung diseaseen_US
dc.subjectpulmonary hypertensionen_US
dc.subjectsystematic reviewen_US
dc.titlePulmonary hypertension in interstitial lung disease: a systematic review and meta-analysis.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleChesten_US
dc.identifier.affiliationRoyal Melbourne Hospital, Victoria, Australia.en_US
dc.identifier.affiliationInstitute for Breathing and Sleepen_US
dc.identifier.affiliationDepartment of Cardiology, Western Health, Victoria, Australia.en_US
dc.identifier.affiliationRoyal Sussex County Hospital, Brighton, United Kingdom.en_US
dc.identifier.affiliationDepartment of Respiratory and Sleep Disorders Medicine, Western Health, Victoria, Australia.en_US
dc.identifier.affiliationUniversity of British Columbia, Vancouver, British Columbia, Canada; Centre for Heart Lung Innovation, Vancouver, British Columbia, Canada.en_US
dc.identifier.affiliationCentral Clinical School, Monash University, Victoria, Australia.en_US
dc.identifier.affiliationRespiratory and Sleep Medicineen_US
dc.identifier.doi10.1016/j.chest.2024.04.025en_US
dc.type.contentTexten_US
dc.identifier.pubmedid38821182-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptRespiratory and Sleep Medicine-
crisitem.author.deptInstitute for Breathing and Sleep-
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