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Title: | Low-risk penicillin allergy delabeling: a scoping review of direct oral challenge practice, implementation, and multi-disciplinary approaches. | Austin Authors: | Mitri, Elise A ;Reynolds, Gemma;Hornung, Catherine J;Trubiano, Jason | Affiliation: | Department of Infectious Diseases, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.;Centre for Antibiotic Allergy and Research, Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia.;National Allergy Centre of Excellence (NACE), Parkville, Victoria, Australia. Infectious Diseases National Allergy Centre of Excellence (NACE), Parkville, Victoria, Australia.;Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia.;Murdoch Children's Research Institute, Parkville, Victoria, Australia. Department of Infectious Diseases, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.;Centre for Antibiotic Allergy and Research, Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia.;National Allergy Centre of Excellence (NACE), Parkville, Victoria, Australia |
Issue Date: | 2024 | Date: | 2023 | Publication information: | Expert Review of Anti-infective Therapy 2024; 22(1-3) | Abstract: | Penicillin allergy is common, and there is increased clinician interest in direct oral challenge (DOC) as a testing strategy for low-risk penicillin allergy. To aid wider implementation of DOC, consensus definitions of low-risk penicillin allergy phenotypes, and standardized approaches to assessment, DOC procedures, and evaluation, are required. This review systematically reviews studies that have utilized penicillin DOC in healthcare settings to identify heterogeneity in implementation approaches and synthesize low-risk definitions, procedures, and evaluation. Opportunity exists to standardize penicillin DOC procedures in patients with a low-risk penicillin allergy to optimize antimicrobial prescribing and reduce the burden of penicillin allergy. Standardizing the definitions of 'low-risk' and 'positive challenge,' and improving the evaluation of patient safety, alongside the development of a unified approach to the structure of undertaking an oral challenge, is likely to increase uptake and confidence among non-allergist clinicians. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/34668 | DOI: | 10.1080/14787210.2023.2296068 | ORCID: | 0000-0002-1250-2847 0009-0001-7045-2040 0000-0002-5111-6367 |
Journal: | Expert Review of Anti-infective Therapy | Start page: | 1 | End page: | 11 | PubMed URL: | 38098185 | ISSN: | 1744-8336 | Type: | Journal Article | Subjects: | Allergy antibiotic antimicrobial stewardship delabeling oral challenge penicillin |
Appears in Collections: | Journal articles |
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