Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/34668
Title: Low-risk penicillin allergy delabeling: a scoping review of direct oral challenge practice, implementation, and multi-disciplinary approaches.
Austin Authors: Mitri, Elise A ;Reynolds, Gemma;Hornung, Catherine J;Trubiano, Jason 
Affiliation: Department of Infectious Diseases, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.;Centre for Antibiotic Allergy and Research, Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia.;National Allergy Centre of Excellence (NACE), Parkville, Victoria, Australia.
Infectious Diseases
National Allergy Centre of Excellence (NACE), Parkville, Victoria, Australia.;Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia.;Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Department of Infectious Diseases, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.;Centre for Antibiotic Allergy and Research, Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia.;National Allergy Centre of Excellence (NACE), Parkville, Victoria, Australia
Issue Date: 2024
Date: 2023
Publication information: Expert Review of Anti-infective Therapy 2024; 22(1-3)
Abstract: Penicillin allergy is common, and there is increased clinician interest in direct oral challenge (DOC) as a testing strategy for low-risk penicillin allergy. To aid wider implementation of DOC, consensus definitions of low-risk penicillin allergy phenotypes, and standardized approaches to assessment, DOC procedures, and evaluation, are required. This review systematically reviews studies that have utilized penicillin DOC in healthcare settings to identify heterogeneity in implementation approaches and synthesize low-risk definitions, procedures, and evaluation. Opportunity exists to standardize penicillin DOC procedures in patients with a low-risk penicillin allergy to optimize antimicrobial prescribing and reduce the burden of penicillin allergy. Standardizing the definitions of 'low-risk' and 'positive challenge,' and improving the evaluation of patient safety, alongside the development of a unified approach to the structure of undertaking an oral challenge, is likely to increase uptake and confidence among non-allergist clinicians.
URI: https://ahro.austin.org.au/austinjspui/handle/1/34668
DOI: 10.1080/14787210.2023.2296068
ORCID: 0000-0002-1250-2847
0009-0001-7045-2040
0000-0002-5111-6367
Journal: Expert Review of Anti-infective Therapy
Start page: 1
End page: 11
PubMed URL: 38098185
ISSN: 1744-8336
Type: Journal Article
Subjects: Allergy
antibiotic
antimicrobial stewardship
delabeling
oral challenge
penicillin
Appears in Collections:Journal articles

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