Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/33571
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dc.contributor.authorDalli, Lachlan L-
dc.contributor.authorBorschmann, Karen-
dc.contributor.authorCooke, Shae-
dc.contributor.authorKilkenny, Monique F-
dc.contributor.authorAndrew, Nadine E-
dc.contributor.authorScott, David-
dc.contributor.authorEbeling, Peter R-
dc.contributor.authorLannin, Natasha A-
dc.contributor.authorGrimley, Rohan-
dc.contributor.authorSundararajan, Vijaya-
dc.contributor.authorKatzenellenbogen, Judith M-
dc.contributor.authorCadilhac, Dominique A-
dc.date2023-
dc.date.accessioned2023-08-23T07:20:05Z-
dc.date.available2023-08-23T07:20:05Z-
dc.date.issued2023-10-
dc.identifier.citationStroke 2023-10; 54(10)en_US
dc.identifier.issn1524-4628-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/33571-
dc.description.abstractFractures are a serious consequence following stroke, but it is unclear how these events influence health-related quality of life (HRQoL). We aimed to compare annualized rates of fractures before and after stroke or transient ischemic attack (TIA), identify associated factors, and examine the relationship with HRQoL after stroke/TIA. Retrospective cohort study using data from the Australian Stroke Clinical Registry (2009-2013) linked with hospital administrative and mortality data. Rates of fractures were assessed in the 1-year period before and after stroke/TIA. Negative binomial regression, with censoring at death, was used to identify factors associated with fractures after stroke/TIA. Respondents provided HRQoL data once between 90 and 180 days after stroke/TIA using the EuroQoL 5-dimensional 3-level instrument. Adjusted logistic regression was used to assess differences in HRQoL at 90 to 180 days by previous fracture. Among 13 594 adult survivors of stroke/TIA (49.7% aged ≥75 years, 45.5% female, 47.9% unable to walk on admission), 618 fractures occurred in the year before stroke/TIA (45 fractures per 1000 person-years) compared with 888 fractures in the year after stroke/TIA (74 fractures per 1000 person-years). This represented a relative increase of 63% (95% CI, 47%-80%). Factors associated with poststroke fractures included being female (incidence rate ratio [IRR], 1.34 [95% CI, 1.05-1.72]), increased age (per 10-year increase, IRR, 1.35 [95% CI, 1.21-1.50]), history of prior fracture(s; IRR, 2.56 [95% CI, 1.77-3.70]), and higher Charlson Comorbidity Scores (per 1-point increase, IRR, 1.18 [95% CI, 1.10-1.27]). Receipt of stroke unit care was associated with fewer poststroke fractures (IRR, 0.67 [95% CI, 0.49-0.93]). HRQoL at 90 to 180 days was worse among patients with prior fracture across the domains of mobility, self-care, usual activities, and pain/discomfort. Fracture risk increases substantially after stroke/TIA, and a history of these events is associated with poorer HRQoL at 90 to 180 days after stroke/TIA.en_US
dc.language.isoeng-
dc.subjectfracturesen_US
dc.subjectoutcomes researchen_US
dc.subjectpopulation registeren_US
dc.subjectquality of lifeen_US
dc.subjectstrokeen_US
dc.titleFracture Risk Increases After Stroke or Transient Ischemic Attack and Is Associated With Reduced Quality of Life.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleStrokeen_US
dc.identifier.affiliationDepartment of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.en_US
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Healthen_US
dc.identifier.affiliationEastern Health, Box Hill, VIC, Australiaen_US
dc.identifier.affiliationDepartment of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.en_US
dc.identifier.affiliationPeninsula Clinical School, Central Clinical School, Monash University, Frankston, VIC, Australia (N.E.A.).;National Centre for Healthy Ageing, Frankston, VIC, Australia.en_US
dc.identifier.affiliationInstitute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, Australia.en_US
dc.identifier.affiliationDepartment of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.en_US
dc.identifier.affiliationDepartment of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, Australia ;Alfred Health, Melbourne, VIC, Australia.en_US
dc.identifier.affiliationSunshine Coast Clinical School, School of Medicine, Griffith University, Birtinya, QLD, Australia.en_US
dc.identifier.affiliationDepartment of Medicine, St Vincent's Hospital, Melbourne Medical School, University of Melbourne, VIC, Australia .en_US
dc.identifier.affiliationSchool of Population and Global Health, The University of Western Australia, Perth, Australia .en_US
dc.identifier.affiliationDepartment of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.en_US
dc.identifier.doi10.1161/STROKEAHA.123.043094en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0003-1449-9132en_US
dc.identifier.orcid0000-0001-5364-2718en_US
dc.identifier.orcid0000-0001-5531-0135en_US
dc.identifier.orcid0000-0002-3375-287Xen_US
dc.identifier.orcid0000-0002-4846-2840en_US
dc.identifier.orcid0000-0001-5226-1972en_US
dc.identifier.orcid0000-0002-2066-8345en_US
dc.identifier.orcid0000-0001-5287-5819en_US
dc.identifier.orcid0000-0001-8162-682Xen_US
dc.identifier.pubmedid37581266-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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