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https://ahro.austin.org.au/austinjspui/handle/1/33152| Title: | Taurine deficiency as a driver of aging. | Austin Authors: | Singh, Parminder;Gollapalli, Kishore;Mangiola, Stefano;Schranner, Daniela;Yusuf, Mohd Aslam;Chamoli, Manish;Shi, Sting L;Lopes Bastos, Bruno;Nair, Tripti;Riermeier, Annett;Vayndorf, Elena M;Wu, Judy Z;Nilakhe, Aishwarya;Nguyen, Christina Q;Muir, Michael;Kiflezghi, Michael G;Foulger, Anna;Junker, Alex;Devine, Jack;Sharan, Kunal;Chinta, Shankar J;Rajput, Swati;Rane, Anand;Baumert, Philipp;Schönfelder, Martin;Iavarone, Francescopaolo;di Lorenzo, Giorgia;Kumari, Swati;Gupta, Alka;Sarkar, Rajesh;Khyriem, Costerwell;Chawla, Amanpreet S;Sharma, Ankur;Sarper, Nazan;Chattopadhyay, Naibedya;Biswal, Bichitra K;Settembre, Carmine;Nagarajan, Perumal;Targoff, Kimara L;Picard, Martin;Gupta, Sarika;Velagapudi, Vidya;Papenfuss, Anthony T;Kaya, Alaattin;Ferreira, Miguel Godinho;Kennedy, Brian K;Andersen, Julie K;Lithgow, Gordon J;Ali, Abdullah Mahmood;Mukhopadhyay, Arnab;Palotie, Aarno;Kastenmüller, Gabi;Kaeberlein, Matt;Wackerhage, Henning;Pal, Bhupinder;Yadav, Vijay K | Affiliation: | Metabolic Research Laboratories, National Institute of Immunology, New Delhi, India. Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. Olivia Newton-John Cancer Research Institute Exercise Biology Group, Technical University of Munich, Munich, Germany.;Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany. Department of Bioengineering, Integral University, Lucknow, India. Buck Institute for Research on Aging, Novato, CA, USA. Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. Institute for Research on Cancer and Aging of Nice (IRCAN), Nice, France. Molecular Aging Laboratory, National Institute of Immunology, New Delhi, India. Exercise Biology Group, Technical University of Munich, Munich, Germany. School of Cancer Medicine, La Trobe University, Bundoora, VIC, Australia. Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA. Metabolic Research Laboratories, National Institute of Immunology, New Delhi, India. Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA. Buck Institute for Research on Aging, Novato, CA, USA. Department of Neurology, Columbia University, New York, NY, USA. Mouse Genetics Project, Wellcome Sanger Institute, Cambridge, UK. Buck Institute for Research on Aging, Novato, CA, USA. Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India. Exercise Biology Group, Technical University of Munich, Munich, Germany. Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy. Metabolic Research Laboratories, National Institute of Immunology, New Delhi, India. Harry Perkins Institute of Medical Research, Perth, WA, Australia.;Curtin Medical School, Curtin University, Perth, WA, Australia. Immunobiology Laboratory, National Institute of Immunology, New Delhi, India.;MRC-Protein Phosphorylation and Ubiquitination Unit, University of Dundee, Dundee, UK. Harry Perkins Institute of Medical Research, Perth, WA, Australia.;Curtin Medical School, Curtin University, Perth, WA, Australia. Pediatrics and Pediatric Hematology, Kocaeli University Hospital, Kocaeli, Turkey. Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India. Metabolic Research Laboratories, National Institute of Immunology, New Delhi, India. Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy.;Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy. Primate Research Facility, National Institute of Immunology, New Delhi, India.;Small Animal Research Facility, National Institute of Immunology, New Delhi, India. Division of Cardiology, Department of Pediatrics, Columbia University, New York, NY, USA. Department of Neurology, Columbia University, New York, NY, USA. Metabolic Research Laboratories, National Institute of Immunology, New Delhi, India. Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland. The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.;Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia. Department of Biology, Virginia Commonwealth University, Richmond, VA, USA. Institute for Research on Cancer and Aging of Nice (IRCAN), Nice, France. Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.;Centre for Healthy Longevity, National University Health System, Singapore, Singapore.;Departments of Biochemistry and Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. Buck Institute for Research on Aging, Novato, CA, USA. Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA. Molecular Aging Laboratory, National Institute of Immunology, New Delhi, India. Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.;Broad Institute of Harvard and MIT, Cambridge, MA, USA.;Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA. Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany. Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA. Exercise Biology Group, Technical University of Munich, Munich, Germany. The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. |
Issue Date: | 9-Jun-2023 | Date: | 2023 | Publication information: | Science (New York, N.Y.) 2023-06-09; 380(6649) | Abstract: | Aging is associated with changes in circulating levels of various molecules, some of which remain undefined. We find that concentrations of circulating taurine decline with aging in mice, monkeys, and humans. A reversal of this decline through taurine supplementation increased the health span (the period of healthy living) and life span in mice and health span in monkeys. Mechanistically, taurine reduced cellular senescence, protected against telomerase deficiency, suppressed mitochondrial dysfunction, decreased DNA damage, and attenuated inflammaging. In humans, lower taurine concentrations correlated with several age-related diseases and taurine concentrations increased after acute endurance exercise. Thus, taurine deficiency may be a driver of aging because its reversal increases health span in worms, rodents, and primates and life span in worms and rodents. Clinical trials in humans seem warranted to test whether taurine deficiency might drive aging in humans. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/33152 | DOI: | 10.1126/science.abn9257 | ORCID: | 0000-0002-2851-6805 0000-0002-9546-2472 0000-0001-7474-836X 0000-0003-2316-318X 0000-0003-2779-9919 0000-0003-0339-7894 0000-0003-0264-7011 0000-0002-0517-9455 0000-0002-5380-4622 0000-0001-9416-3350 0000-0002-6669-5330 0000-0001-5596-3443 0000-0003-3318-3686 0000-0003-4135-9741 0000-0003-1746-7160 0000-0003-2139-2544 0000-0001-6386-6790 0000-0003-2079-965X 0000-0001-5886-5291 0000-0002-5463-1954 0000-0002-3003-3378 0000-0002-8855-1848 0000-0001-8659-5268 0000-0003-0607-8098 0000-0001-8126-3475 0000-0001-7779-031X 0000-0003-2078-2532 0000-0002-6862-136X 0000-0003-1599-774X 0000-0003-2473-0246 0000-0002-5927-3244 0000-0002-5829-8589 0000-0003-4557-4633 0000-0002-6066-6002 0000-0003-2835-0478 0000-0002-3054-0337 0000-0002-1102-8506 0000-0002-6132-5197 0000-0002-8363-7183 0000-0002-5754-1874 0000-0002-8953-3043 0000-0002-4007-6769 0000-0002-5266-7849 0000-0002-2368-7322 0000-0002-1311-3421 0000-0002-3684-4331 0000-0003-2345-2846 |
Journal: | Science (New York, N.Y.) | Start page: | eabn9257 | PubMed URL: | 37289866 | ISSN: | 1095-9203 | Type: | Journal Article | Subjects: | Aging/blood Aging/drug effects Aging/metabolism Longevity/drug effects Longevity/physiology Taurine/blood Taurine/deficiency Taurine/pharmacology DNA Damage/drug effects Telomerase/metabolism |
| Appears in Collections: | Journal articles |
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