Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/32327
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dc.contributor.authorShuping, Joanna L-
dc.contributor.authorMatthews, Dawn C-
dc.contributor.authorAdamczuk, Katarzyna-
dc.contributor.authorScott, David-
dc.contributor.authorRowe, Christopher C-
dc.contributor.authorKreisl, William C-
dc.contributor.authorJohnson, Sterling C-
dc.contributor.authorLukic, Ana S-
dc.contributor.authorJohnson, Keith A-
dc.contributor.authorRosa-Neto, Pedro-
dc.contributor.authorAndrews, Randolph D-
dc.contributor.authorVan Laere, Koen-
dc.contributor.authorCordes, Lindsay-
dc.contributor.authorWard, Larry-
dc.contributor.authorWilde, Claire L-
dc.contributor.authorBarakos, Jerome-
dc.contributor.authorPurcell, Derk D-
dc.contributor.authorDevanand, Davangere P-
dc.contributor.authorStern, Yaakov-
dc.contributor.authorLuchsinger, Jose A-
dc.contributor.authorSur, Cyrille-
dc.contributor.authorPrice, Julie C-
dc.contributor.authorBrickman, Adam M-
dc.contributor.authorKlunk, William E-
dc.contributor.authorBoxer, Adam L-
dc.contributor.authorMathotaarachchi, Sulantha S-
dc.contributor.authorLao, Patrick J-
dc.contributor.authorEvelhoch, Jeffrey L-
dc.date2023-
dc.date.accessioned2023-03-22T01:49:30Z-
dc.date.available2023-03-22T01:49:30Z-
dc.date.issued2023-
dc.identifier.citationAlzheimer's & dementia (New York, N. Y.) 2023; 9(1): e12372en_US
dc.identifier.issn2352-8737-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/32327-
dc.description.abstractThe positron emission tomography (PET) radiotracer [18F]MK-6240 exhibits high specificity for neurofibrillary tangles (NFTs) of tau protein in Alzheimer's disease (AD), high sensitivity to medial temporal and neocortical NFTs, and low within-brain background. Objectives were to develop and validate a reproducible, clinically relevant visual read method supporting [18F]MK-6240 use to identify and stage AD subjects versus non-AD and controls. Five expert readers used their own methods to assess 30 scans of mixed diagnosis (47% cognitively normal, 23% mild cognitive impairment, 20% AD, 10% traumatic brain injury) and provided input regarding regional and global positivity, features influencing assessment, confidence, practicality, and clinical relevance. Inter-reader agreement and concordance with quantitative values were evaluated to confirm that regions could be read reliably. Guided by input regarding clinical applicability and practicality, read classifications were defined. The readers read the scans using the new classifications, establishing by majority agreement a gold standard read for those scans. Two naïve readers were trained and read the 30-scan set, providing initial validation. Inter-rater agreement was further tested by two trained independent readers in 131 scans. One of these readers used the same method to read a full, diverse database of 1842 scans; relationships between read classification, clinical diagnosis, and amyloid status as available were assessed. Four visual read classifications were determined: no uptake, medial temporal lobe (MTL) only, MTL and neocortical uptake, and uptake outside MTL. Inter-rater kappas were 1.0 for the naïve readers gold standard scans read and 0.98 for the independent readers 131-scan read. All scans in the full database could be classified; classification frequencies were concordant with NFT histopathology literature. This four-class [18F]MK-6240 visual read method captures the presence of medial temporal signal, neocortical expansion associated with disease progression, and atypical distributions that may reflect different phenotypes. The method demonstrates excellent trainability, reproducibility, and clinical relevance supporting clinical use. A visual read method has been developed for [18F]MK-6240 tau positron emission tomography.The method is readily trainable and reproducible, with inter-rater kappas of 0.98.The read method has been applied to a diverse set of 1842 [18F]MK-6240 scans.All scans from a spectrum of disease states and acquisitions could be classified.Read classifications are consistent with histopathological neurofibrillary tangle staging literature.en_US
dc.language.isoeng-
dc.subjectAlzheimer's diseaseen_US
dc.subjectMK‐6240en_US
dc.subject[18F]MK‐6240en_US
dc.subjectflorquinitauen_US
dc.subjectneurofibrillary tanglesen_US
dc.subjectpositron emission tomographyen_US
dc.subjecttauen_US
dc.subjecttraceren_US
dc.subjectvisual readen_US
dc.titleDevelopment, initial validation, and application of a visual read method for [18F]MK-6240 tau PET.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleAlzheimer's & Dementia (New York, N. Y.)en_US
dc.identifier.affiliationEnigma Biomedical Group Toronto Ontario Canada.en_US
dc.identifier.affiliationADM Diagnostics, Inc. Northbrook Illinois USA.en_US
dc.identifier.affiliationClario, Inc. San Mateo California USA.en_US
dc.identifier.affiliationMolecular Imaging and Therapyen_US
dc.identifier.affiliationDepartment of Neurology The Taub Institute for Research on Alzheimer's Disease and the Aging Brain Columbia University New York New York USA.en_US
dc.identifier.affiliationDepartment of Medicine Division of Geriatrics Alzheimer's Disease Research Center, University of Wisconsin Madison Wisconsin USA.en_US
dc.identifier.affiliationADM Diagnostics, Inc. Northbrook Illinois USA.en_US
dc.identifier.affiliationThe Gordon Center for Medical Imaging Department of Neurology Center for Alzheimer Research and Treatment Brigham and Women's Hospital Boston Massachusetts USA.en_US
dc.identifier.affiliationMontreal Neurological Institute McGill University Montréal Quebec Canada.en_US
dc.identifier.affiliationNuclear Medicine and Molecular Imaging Department of Imaging and Pathology KU Leuven Leuven Belgium.en_US
dc.identifier.affiliationStatKing Clinical Services Fairfield Ohio USA.en_US
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Healthen_US
dc.identifier.affiliationCerveau Technologies, Inc. Knoxville Tennessee USA.en_US
dc.identifier.affiliationDepartment of Neurology The Taub Institute for Research on Alzheimer's Disease and the Aging Brain Columbia University New York New York USA.en_US
dc.identifier.affiliationColumbia University Irving Medical Center Vagelos College of Physicians and Surgeons New York New York USA.en_US
dc.identifier.affiliationMerck & Co., Inc. West Point Pennsylvania USA.en_US
dc.identifier.affiliationDepartment of Radiology Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital Harvard Medical School Charlestown Massachusetts USA.en_US
dc.identifier.affiliationDepartment of Neurology The Taub Institute for Research on Alzheimer's Disease and the Aging Brain Columbia University New York New York USA.en_US
dc.identifier.affiliationDepartment of Psychiatry University of Pittsburgh Pittsburgh Pennsylvania USA.en_US
dc.identifier.affiliationDepartment of Neurology Memory and Aging Center University of California San Francisco California USA.en_US
dc.identifier.affiliationEnigma Biomedical Group Toronto Ontario Canada.en_US
dc.identifier.affiliationDepartment of Neurology The Taub Institute for Research on Alzheimer's Disease and the Aging Brain Columbia University New York New York USA.en_US
dc.identifier.doi10.1002/trc2.12372en_US
dc.type.contentTexten_US
dc.identifier.pubmedid36873926-
dc.description.volume9-
dc.description.issue1-
dc.description.startpagee12372-
local.name.researcherRowe, Christopher C
item.grantfulltextnone-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.deptMolecular Imaging and Therapy-
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