Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/32272
Full metadata record
DC FieldValueLanguage
dc.contributor.authorCummins, Tia Louise-
dc.contributor.authorDoré, Vincent-
dc.contributor.authorFeizpour, Azadeh-
dc.contributor.authorKrishnadas, Natasha-
dc.contributor.authorBourgeat, Pierrick-
dc.contributor.authorElias, Alby-
dc.contributor.authorLamb, Fiona-
dc.contributor.authorWilliams, Robert-
dc.contributor.authorHopwood, Malcolm John-
dc.contributor.authorLandau, Susan-
dc.contributor.authorVillemagne, Victor L-
dc.contributor.authorWeiner, Michael-
dc.contributor.authorRowe, Christopher C-
dc.date2023-
dc.date.accessioned2023-03-08T01:06:41Z-
dc.date.available2023-03-08T01:06:41Z-
dc.date.issued2023-02-28-
dc.identifier.citationJournal of Neurotrauma 2023, 40(11-12)en_US
dc.identifier.issn1557-9042-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/32272-
dc.description.abstractTraumatic Brain Injury (TBI) is common amongst military veterans and has been associated with an increased risk of dementia. It is unclear if this is due to increased risk for Alzheimer's disease (AD) or other mechanisms. This case control study sought evidence for AD, as defined by the 2018 NIA-AA research framework, by measuring tau, β-amyloid and glucose metabolism using positron emission tomography (PET) in veterans with service-related TBI. Seventy male Vietnam war veterans - 40 with TBI (aged 68.0±2.5 years) and 30 controls (aged 70.1±5.3 years) - with no prior diagnosis of dementia or mild cognitive impairment underwent β-amyloid (18F-Florbetaben), tau (18F-Flortaucipir) and 18F-FDG PET. The TBI cohort included 15 participants with mild, 16 with moderate, and 9 with severe injury. β-amyloid level was calculated using the Centiloid (CL) method and tau was measured by Standardized Uptake Value Ratios (SUVR) using the cerebellar cortex as reference region. Analyses were adjusted for age and APOE-e4. The findings were validated in an independent cohort from the ADNI-DOD study. There were no significant nor trending differences in β-amyloid or tau levels or 18F-FDG uptake between the TBI and control groups before and after controlling for covariates. The β-amyloid and tau findings were replicated in the ADNI-DOD validation cohort and persisted when the AIBL-VETS and ADNI-DOD cohorts were combined (114 TBI vs 87 controls in total). In conclusion, no increase in the later life accumulation of the neuropathological markers of AD in veterans with a remote history of TBI was identified.en_US
dc.language.isoeng-
dc.subjectBETA AMYLOIDen_US
dc.subjectBIOMARKERSen_US
dc.subjectNEURODEGENERATIVE DISORDERSen_US
dc.subjectPET SCANNINGen_US
dc.subjectTRAUMATIC BRAIN INJURYen_US
dc.titleTau, β-amyloid, and glucose metabolism following service-related Traumatic Brain Injury in Vietnam war veterans: The AIBL-VETS study.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleJournal of Neurotraumaen_US
dc.identifier.affiliationMolecular Imaging and Therapyen_US
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Healthen_US
dc.identifier.affiliationThe Australian eHealth Research Centre, CSIRO, Brisbane, Queensland, Australiaen_US
dc.identifier.affiliationMelbourne Brain Centre Imaging Unit, The University of Melbourne, Melbourne, Victoria, Australia.en_US
dc.identifier.affiliationDepartment of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia; mhopwood@unimelb.edu.au.en_US
dc.identifier.affiliationHelen Wills Neuroscience Institute, 71433, Berkeley, California, United States; slandau@berkeley.edu.en_US
dc.identifier.affiliationUniversity of California, San Francisco, California, United States; Michael.Weiner@ucsf.edu.en_US
dc.identifier.doi10.1089/neu.2022.0172en_US
dc.type.contentTexten_US
dc.identifier.pubmedid36855333-
local.name.researcherDoré, Vincent
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptMolecular Imaging and Therapy-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

112
checked on Dec 25, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.