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https://ahro.austin.org.au/austinjspui/handle/1/32176| Title: | Plasma Glial Fibrillary Acidic Protein Is Associated with 18F-SMBT-1 PET: Two Putative Astrocyte Reactivity Biomarkers for Alzheimer's Disease. | Austin Authors: | Chatterjee, Pratishtha;Doré, Vincent ;Pedrini, Steve;Krishnadas, Natasha ;Thota, Rohith;Bourgeat, Pierrick;Ikonomovic, Milos D;Rainey-Smith, Stephanie R;Burnham, Samantha C;Fowler, Christopher;Taddei, Kevin;Mulligan, Rachel S ;Ames, David;Masters, Colin L ;Fripp, Jürgen;Rowe, Christopher C ;Martins, Ralph N;Villemagne, Victor L | Affiliation: | Macquarie Medical School, Macquarie University, North Ryde, New South Wales, Australia. The Australian eHealth Research Centre, CSIRO, Brisbane, Queensland, Australia. School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia. Health and Biosecurity Flagship, The Australian eHealth Research Centre, Queensland, Australia. Department of Neurology, University of Pittsburgh, Pennsylvania, PA, USA. The Florey Institute of Neuroscience and Mental Health Molecular Imaging and Therapy National Ageing Research Institute, Parkville, Victoria, Australia. |
Issue Date: | 9-Feb-2023 | Date: | 2023 | Publication information: | Journal of Alzheimer's disease : JAD 2023; 92(2) | Abstract: | Astrocyte reactivity is an early event along the Alzheimer's disease (AD) continuum. Plasma glial fibrillary acidic protein (GFAP), posited to reflect astrocyte reactivity, is elevated across the AD continuum from preclinical to dementia stages. Monoamine oxidase-B (MAO-B) is also elevated in reactive astrocytes observed using 18F-SMBT-1 PET in AD. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/32176 | DOI: | 10.3233/JAD-220908 | ORCID: | Journal: | Journal of Alzheimer's Disease | Start page: | 615 | End page: | 628 | PubMed URL: | 36776057 | PubMed URL: | https://pubmed.ncbi.nlm.nih.gov/36776057/ | ISSN: | 1875-8908 | Type: | Journal Article | Subjects: | 18F-SMBT-1 Astrocyte reactivity biomarkers glial fibrillary acidic protein monoamine oxidase B positron emission tomography Alzheimer Disease/metabolism Amyloid beta-Peptides/metabolism Astrocytes/metabolism Glial Fibrillary Acidic Protein/metabolism Cognitive Dysfunction/genetics Brain/diagnostic imaging Brain/metabolism Positron-Emission Tomography/methods Biomarkers/metabolism Apolipoproteins E/metabolism tau Proteins/metabolism |
| Appears in Collections: | Journal articles |
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