Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/32173
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dc.contributor.authorBatchelor, Peter-
dc.contributor.authorBernard, Stephen-
dc.contributor.authorGantner, Dashiell-
dc.contributor.authorUdy, Andrew-
dc.contributor.authorBoard, Jasmin-
dc.contributor.authorFitzgerald, Mark-
dc.contributor.authorSkeers, Peta-
dc.contributor.authorBattistuzzo, Camila-
dc.contributor.authorStephenson, Mick-
dc.contributor.authorSmith, Karen-
dc.contributor.authorNunn, Andrew K-
dc.date2023-
dc.date.accessioned2023-02-21T23:53:53Z-
dc.date.available2023-02-21T23:53:53Z-
dc.date.issued2023-02-13-
dc.identifier.citationTherapeutic Hypothermia and Temperature Management 2023, 13(2)en_US
dc.identifier.issn2153-7933-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/32173-
dc.description.abstractCervical spinal cord injury (SCI) usually results in severe, long-term disability. Early therapeutic hypothermia (33-34°C) has been used to improve outcomes in preclinical studies, but previous clinical studies have commenced cooling after arrival at hospital. The objective of the study is to determine the feasibility and safety of early therapeutic hypothermia initiated by paramedics and maintained for up to 24 hours in hospital in patients with SCI. This is a pilot clinical study. The study was undertaken at Ambulance Victoria and The Alfred Hospital, Victoria, Australia. A total of 17 consecutive patients with suspected acute traumatic cervical SCI were enrolled. Patients with suspected cervical SCI were administered a bolus (up to 20 mL/kg) intravenous (IV) cold (4°C) normal saline in the prehospital phase of care. After hospital admission and spinal imaging, further cooling used IV catheter temperature control or surface cooling. Major complications and long-term outcomes were compared with historical controls admitted to the same center before the study. A decrease in core temperature of 1.1°C was achieved during prehospital care and the target temperature was achieved in 6 hours with mechanical temperature management devices in the hospital. There were no major safety concerns. Patients with motor complete SCI who underwent early decompressive surgery had a favorable rate of partial spinal cord recovery compared with historical controls. Therapeutic hypothermia induced using bolus, large-volume, ice-cold saline prehospital and maintained for 24 hours using mechanical devices appears to be feasible and safe in patients with SCI. Larger trials need to be undertaken to determine whether prehospital cooling combined with early decompressive surgery improves outcomes in patients with complete cervical SCI. Australian and New Zealand Clinical Trials Registry (ACTRN12616001086459).en_US
dc.language.isoeng-
dc.subjectcervical spinal cord injuryen_US
dc.subjectdecompressive surgeryen_US
dc.subjecttherapeutic hypothermiaen_US
dc.titleImmediate Cooling and Early Decompression for the Treatment of Cervical Spinal Cord Injury: A Safety and Feasibility Study.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleTherapeutic Hypothermia and Temperature Managementen_US
dc.identifier.affiliationDepartment of Neurology, University Hospital Geelong, Geelong, Australia.en_US
dc.identifier.affiliationIntensive Care Unit, The Alfred Hospital, Melbourne, Australia.en_US
dc.identifier.affiliationAmbulance Victoria, Doncaster, Australia.en_US
dc.identifier.affiliationPrehospital, Emergency and Trauma Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.en_US
dc.identifier.affiliationVictorian Spinal Cord Serviceen_US
dc.identifier.doi10.1089/ther.2022.0046en_US
dc.type.contentTexten_US
dc.identifier.pubmedid36779969-
local.name.researcherNunn, Andrew K
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptVictorian Spinal Cord Service-
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