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Title: | Intoxications in an Australian Emergency Department Involving 'Nitazene' Benzylbenzimidazole Synthetic Opioids (Etodesnitazene, Butonitazene and Protonitazene). | Austin Authors: | Schumann, J L;Syrjanen, R;Alford, K;Mashetty, S;Castle, J W;Rotella, Joe Anthony;Maplesden, J;Greene, Shaun L | Affiliation: | Victorian Poisons Information Centre Emergency Department of Emergency Medicine, Northern Hospital, Melbourne, Australia Monash Addiction Research Centre, Melbourne, Australia Department of Critical Care, University of Melbourne Department of Emergency Medicine, Dandenong Hospital, Melbourne, Australia Department of Emergency Medicine, St Vincent's Hospital, Melbourne, Australia Department of Forensic Medicine, Monash University Victorian Institute of Forensic Medicine, Melbourne, Australia |
Issue Date: | 19-Aug-2022 | Date: | 2022 | Publication information: | Journal of Analytical Toxicology 2022; 47(1):e6-e9 | Abstract: | Benzimidazole synthetic opioids are highly potent μ-opioid receptor agonists with heroin-like effects, including dose-dependent respiratory depression and a high risk of abuse and toxicity. Benzimidazoles were first detected in 2019 in Europe and Canada, with analytical confirmation of etodesnitazene, protonitazene and butonitazene in 2021. We report the first detections of these compounds in Australia, in two patients presenting with drug toxicity to Emergency Departments in the state of Victoria. Case 1 was a female in her 20s who rectally administered etodesnitazene and was found unconscious with a respiratory depression and hypotension. Case 2 was a female in her 30s who presented to the ED in a sedated state after taking a formulation of protonitazene which also contained butonitazene, in addition to methylamphetamine. She responded positively to naloxone. Novel synthetic opioids were used with prior experience of the formulations purchased, however the unpredictability of their effects was demonstrated by the acute toxicity experienced with this occasion of use. Toxicosurveillance of Emergency Department presentations with analytical confirmation of drugs is crucial in identifying emerging drugs in the community and informing harm reduction strategies. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/30742 | DOI: | 10.1093/jat/bkac062 | ORCID: | 0000-0002-7423-2467 0000-0003-2068-8757 |
Journal: | Journal of Analytical Toxicology | Start page: | e6 | End page: | e9 | PubMed URL: | 35983900 | PubMed URL: | https://pubmed.ncbi.nlm.nih.gov/35983900/ | ISSN: | 1945-2403 | Type: | Journal Article | Subjects: | drug toxicity early warning system naloxone novel psychoactive substance novel synthetic opioid |
Appears in Collections: | Journal articles |
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