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https://ahro.austin.org.au/austinjspui/handle/1/30711| Title: | A companion to the preclinical common data elements for genomics, transcriptomics and epigenomics data in rodent epilepsy models. A Report of the TASK3-WG4 Omics Working Group of the ILAE/AES Joint Translational Task Force. | Austin Authors: | van Vliet, Erwin A;Hildebrand, Michael S ;Mills, James D;Brennan, Gary P;Eid, Tore;Masino, Susan A;Whittemore, Vicky;Bindila, Laura;Wang, Kevin K;Patel, Manisha;Perucca, Piero ;Reid, Christopher A | Affiliation: | The Florey Institute of Neuroscience and Mental Health Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, the Netherlands.. Epilepsy Research Centre Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia.. Comprehensive Epilepsy Program Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia.. Departments of Neurology, The Royal Melbourne Hospital, Melbourne, Victoria, Australia.. Department of Neurology, Alfred Health, Melbourne, Victoria, Australia.. Amsterdam UMC, University of Amsterdam, Dept (Neuro)Pathology, Amsterdam Neuroscience, Amsterdam, the Netherlands.. UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin, Ireland.. Department of Laboratory Medicine, Yale School of Medicine, New Haven, Connecticut, USA.. Neuroscience Program and Psychology Department, Life Sciences Center, Trinity College, Hartford, Connecticut, USA.. Division of Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.. Clinical Lipidomics Unit, Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany.. Department of Emergency Medicine, Psychiatry and Neuroscience, University of Florida, Gainesville, Florida, USA.. Department of Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.. Amsterdam UMC, University of Amsterdam, Dept (Neuro)Pathology, Amsterdam Neuroscience, Amsterdam, the Netherlands.. FutureNeuro Research Centre, Royal College of Surgeons in Ireland, Dublin, Ireland.. Epilepsy Genetics Program, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.. Brain Rehabilitation Research Center, Malcom Randall VA Medical Center, North Florida/South Georgia Veterans Health System, Gainesville, Florida, USA.. |
Issue Date: | 11-Aug-2022 | Date: | 2022 | Publication information: | Epilepsia Open 2022; online first: 11 August | Abstract: | The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various preclinical epilepsy research disciplines. The aim of the CDEs is to improve the standardization of experimental designs across a range of epilepsy research related methods. Here, we have generated CDE tables with key parameters and case report forms (CRFs) containing the essential contents of the study protocols for genomics, transcriptomics and epigenomics in rodent models of epilepsy, with a specific focus on adult rats and mice. We discuss the important elements that need to be considered for genomics, transcriptomics and epigenomics methodologies, providing a rationale for the parameters that should be collected. This is the first in a two-part series of omics papers with the second instalment to cover proteomics, lipidomics, and metabolomics in adult rodents. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/30711 | DOI: | 10.1002/epi4.12640 | ORCID: | 0000-0001-5747-3202 0000-0001-9217-6393 0000-0003-4237-4900 0000-0002-7855-7066 0000-0002-1457-8028 0000-0003-2739-0515 |
Journal: | Epilepsia Open | PubMed URL: | 35950645 | PubMed URL: | https://pubmed.ncbi.nlm.nih.gov/35950645/ | Type: | Journal Article | Subjects: | common data elements mouse omic data processing preclinical rat |
| Appears in Collections: | Journal articles |
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