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Title: | Visually Identified Tau 18F-MK6240 PET Patterns in Symptomatic Alzheimer's Disease. | Austin Authors: | Krishnadas, Natasha ;Huang, Kun ;Schultz, Stephanie A;Doré, Vincent ;Bourgeat, Pierrick;Goh, Anita M Y;Lamb, Fiona ;Bozinovski, Svetlana ;Burnham, Samantha C;Robertson, Joanne S;Laws, Simon M;Maruff, Paul;Masters, Colin L ;Villemagne, Victor L ;Rowe, Christopher C | Affiliation: | Florey Department of Neurosciences & Mental Health, The University of Melbourne, Parkville, VIC, Australia.. Molecular Imaging and Therapy National Ageing Research Institute, Parkville, VIC, Australia.. Health and Biosecurity Flagship, The Australian eHealth Research Centre, Melbourne, Victoria, Australia.. Health and Biosecurity Flagship, The Australian eHealth Research Centre, Brisbane, QLD, Australia.. Department of Psychiatry, The University of Melbourne, Parkville, VIC, Australia.. Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia.. The Florey Institute of Neuroscience and Mental Health Centre for Precision Health, Edith Cowan University, Perth, WA, Australia.. Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.. |
Issue Date: | 7-Jul-2022 | Date: | 2022 | Publication information: | Journal of Alzheimer's Disease: JAD 2022; 88(4): 1627-1637 | Abstract: | In Alzheimer's disease, heterogeneity has been observed in the postmortem distribution of tau neurofibrillary tangles. Visualizing the topography of tau in vivo may facilitate clinical trials and clinical practice. This study aimed to investigate whether tau distribution patterns that are limited to mesial temporal lobe (MTL)/limbic regions, and those that spare MTL regions, can be visually identified using 18F-MK6240, and whether these patterns are associated with different demographic and cognitive profiles. Tau 18F-MK6240 PET images of 151 amyloid-β positive participants with mild cognitive impairment (MCI) and dementia were visually rated as: tau negative, limbic predominant (LP), MTL-sparing, and Typical by two readers. Groups were evaluated for differences in age, APOE ɛ4 carriage, hippocampal volumes, and cognition (MMSE, composite memory and non-memory scores). Voxel-wise contrasts were also performed. Visual rating resulted in 59.6% classified as Typical, 17.9% as MTL-sparing, 9.9% LP, and 12.6% as tau negative. Intra-rater and inter-rater reliability was strong (Cohen's kappa values of 0.89 and 0.86 respectively). Tracer retention in a "hook"-like distribution on sagittal sequences was observed in the LP and Typical groups. The visually classified MTL-sparing group had lower APOE ɛ4 carriage and relatively preserved hippocampal volumes. Higher MTL tau was associated with greater amnestic cognitive impairment. High cortical tau was associated with greater impairments on non-memory domains of cognition, and individuals with high cortical tau were more likely to have dementia than MCI. Tau distribution patterns can be visually identified using 18F-MK6240 PET and are associated with differences in APOE ɛ4 carriage, hippocampal volumes, and cognition. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/30564 | DOI: | 10.3233/JAD-215558 | ORCID: | 0000-0002-5374-2839 0000-0001-8460-4415 0000-0002-8051-0558 0000-0001-6533-8641 0000-0002-6947-9537 0000-0003-3072-7940 0000-0002-5832-9875 0000-0003-3910-2453 |
Journal: | Journal of Alzheimer's disease : JAD | PubMed URL: | 35811517 | PubMed URL: | https://pubmed.ncbi.nlm.nih.gov/35811517/ | Type: | Journal Article | Subjects: | 18F-MK6240 Alzheimer’s disease cognition patterns positron emission tomography tau |
Appears in Collections: | Journal articles |
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