Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/30108
Title: Insulin resistance, cognition and Alzheimer's disease biomarkers: Evidence that CSF Aβ42 moderates the association between insulin resistance and increased CSF tau levels.
Austin Authors: Woodfield, Amy;Porter, Tenielle;Gilani, Israa;Noordin, Siti;Li, Qiao-Xin;Collins, Steven;Martins, Ralph N;Maruff, Paul;Masters, Colin L ;Rowe, Christopher C ;Villemagne, Victor L ;Doré, Vincent ;Newsholme, Philip;Laws, Simon M;Verdile, Giuseppe
Affiliation: Molecular Imaging and Therapy
The Florey Institute of Neuroscience and Mental Health
School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia
Cogstate Ltd, Melbourne, VIC, Australia
Centre for Precision Health, Edith Cowan University, Joondalup, WA, Australia
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA..
Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, NSW, Australia
eHealth, CSIRO Health and Biosecurity, Herston, QLD, Australia
Curtin Medical School, Curtin University, Bentley, WA, Australia
Curtin Health Innovation Research Institute, Curtin University, Bentley, WA, Australia
Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia
Issue Date: Jun-2022
Date: 2022-03-11
Publication information: Neurobiology of Aging 2022; 114: 38-48
Abstract: Mounting evidence implicates insulin resistance (IR) with reduced cognition, increased dementia risk and changes in Alzheimer's disease biomarkers. It's unclear how, and at what stage IR has the greatest impact on Alzheimer's disease biomarker progression indicative of cognitive decline. Exploration of potential factors influencing this relationship continue. We have previously reported IR to be associated with cognitive function, and increased CSF tau in a cognitively unimpaired cohort. Now, we aimed to determine if CSF total (t-tau) or phosphorylated tau (p-tau) mediated the relationship between HOMA-IR and cognition, and explore sex or amyloid-β (Aβ) biomarkers as moderators of this relationship. Mediation analysis demonstrated that CSF tau does not directly influence the association between HOMA-IR and cognition. Moderation analysis revealed CSF Aβ42 moderates the relationships between HOMA-IR and CSF tau. The combination of lower CSF Aβ42 and higher HOMA-IR was associated with increases in CSF tau. The CSF Aβ42 moderation finding has potential to be considered when assessing type 2 diabetic risk for tau pathology and cognitive decline.
URI: https://ahro.austin.org.au/austinjspui/handle/1/30108
DOI: 10.1016/j.neurobiolaging.2022.03.004
ORCID: 0000-0002-8051-0558
0000-0002-6947-9537
0000-0002-5832-9875
0000-0003-3910-2453
0000-0003-3072-7940
0000-0002-5245-6611
0000-0001-8438-3763
Journal: Neurobiology of Aging
PubMed URL: 35381406
PubMed URL: https://pubmed.ncbi.nlm.nih.gov/35381406/
Type: Journal Article
Subjects: Alzheimer's disease
Amyloid
Biomarkers
Cognitive Function
Insulin Resistance
Tau
Appears in Collections:Journal articles

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