Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/30108
Title: | Insulin resistance, cognition and Alzheimer's disease biomarkers: Evidence that CSF Aβ42 moderates the association between insulin resistance and increased CSF tau levels. | Austin Authors: | Woodfield, Amy;Porter, Tenielle;Gilani, Israa;Noordin, Siti;Li, Qiao-Xin;Collins, Steven;Martins, Ralph N;Maruff, Paul;Masters, Colin L ;Rowe, Christopher C ;Villemagne, Victor L ;Doré, Vincent ;Newsholme, Philip;Laws, Simon M;Verdile, Giuseppe | Affiliation: | Molecular Imaging and Therapy The Florey Institute of Neuroscience and Mental Health School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia Cogstate Ltd, Melbourne, VIC, Australia Centre for Precision Health, Edith Cowan University, Joondalup, WA, Australia Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.. Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, NSW, Australia eHealth, CSIRO Health and Biosecurity, Herston, QLD, Australia Curtin Medical School, Curtin University, Bentley, WA, Australia Curtin Health Innovation Research Institute, Curtin University, Bentley, WA, Australia Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia |
Issue Date: | Jun-2022 | Date: | 2022-03-11 | Publication information: | Neurobiology of Aging 2022; 114: 38-48 | Abstract: | Mounting evidence implicates insulin resistance (IR) with reduced cognition, increased dementia risk and changes in Alzheimer's disease biomarkers. It's unclear how, and at what stage IR has the greatest impact on Alzheimer's disease biomarker progression indicative of cognitive decline. Exploration of potential factors influencing this relationship continue. We have previously reported IR to be associated with cognitive function, and increased CSF tau in a cognitively unimpaired cohort. Now, we aimed to determine if CSF total (t-tau) or phosphorylated tau (p-tau) mediated the relationship between HOMA-IR and cognition, and explore sex or amyloid-β (Aβ) biomarkers as moderators of this relationship. Mediation analysis demonstrated that CSF tau does not directly influence the association between HOMA-IR and cognition. Moderation analysis revealed CSF Aβ42 moderates the relationships between HOMA-IR and CSF tau. The combination of lower CSF Aβ42 and higher HOMA-IR was associated with increases in CSF tau. The CSF Aβ42 moderation finding has potential to be considered when assessing type 2 diabetic risk for tau pathology and cognitive decline. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/30108 | DOI: | 10.1016/j.neurobiolaging.2022.03.004 | ORCID: | 0000-0002-8051-0558 0000-0002-6947-9537 0000-0002-5832-9875 0000-0003-3910-2453 0000-0003-3072-7940 0000-0002-5245-6611 0000-0001-8438-3763 |
Journal: | Neurobiology of Aging | PubMed URL: | 35381406 | PubMed URL: | https://pubmed.ncbi.nlm.nih.gov/35381406/ | Type: | Journal Article | Subjects: | Alzheimer's disease Amyloid Biomarkers Cognitive Function Insulin Resistance Tau |
Appears in Collections: | Journal articles |
Show full item record
Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.