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dc.contributor.authorBlokland, Gabriëlla A M-
dc.contributor.authorGrove, Jakob-
dc.contributor.authorChen, Chia-Yen-
dc.contributor.authorCotsapas, Chris-
dc.contributor.authorTobet, Stuart-
dc.contributor.authorHanda, Robert-
dc.contributor.authorSt Clair, David-
dc.contributor.authorLencz, Todd-
dc.contributor.authorMowry, Bryan J-
dc.contributor.authorPeriyasamy, Sathish-
dc.contributor.authorCairns, Murray J-
dc.contributor.authorTooney, Paul A-
dc.contributor.authorWu, Jing Qin-
dc.contributor.authorKelly, Brian D-
dc.contributor.authorKirov, George-
dc.contributor.authorSullivan, Patrick F-
dc.contributor.authorCorvin, Aiden-
dc.contributor.authorRiley, Brien P-
dc.contributor.authorEsko, Tõnu-
dc.contributor.authorMilani, Lili-
dc.contributor.authorJönsson, Erik G-
dc.contributor.authorPalotie, Aarno-
dc.contributor.authorEhrenreich, Hannelore-
dc.contributor.authorBegemann, Martin-
dc.contributor.authorSteixner-Kumar, Agnes-
dc.contributor.authorSham, Pak C-
dc.contributor.authorIwata, Nakao-
dc.contributor.authorWeinberger, Daniel R-
dc.contributor.authorGejman, Pablo V-
dc.contributor.authorSanders, Alan R-
dc.contributor.authorBuxbaum, Joseph D-
dc.contributor.authorRujescu, Dan-
dc.contributor.authorGiegling, Ina-
dc.contributor.authorKonte, Bettina-
dc.contributor.authorHartmann, Annette M-
dc.contributor.authorBramon, Elvira-
dc.contributor.authorMurray, Robin M-
dc.contributor.authorPato, Michele T-
dc.contributor.authorLee, Jimmy-
dc.contributor.authorMelle, Ingrid-
dc.contributor.authorMolden, Espen-
dc.contributor.authorOphoff, Roel A-
dc.contributor.authorMcQuillin, Andrew-
dc.contributor.authorBass, Nicholas J-
dc.contributor.authorAdolfsson, Rolf-
dc.contributor.authorMalhotra, Anil K-
dc.contributor.authorMartin, Nicholas G-
dc.contributor.authorFullerton, Janice M-
dc.contributor.authorMitchell, Philip B-
dc.contributor.authorSchofield, Peter R-
dc.contributor.authorForstner, Andreas J-
dc.contributor.authorDegenhardt, Franziska-
dc.contributor.authorSchaupp, Sabrina-
dc.contributor.authorComes, Ashley L-
dc.contributor.authorKogevinas, Manolis-
dc.contributor.authorGuzman-Parra, José-
dc.contributor.authorReif, Andreas-
dc.contributor.authorStreit, Fabian-
dc.contributor.authorSirignano, Lea-
dc.contributor.authorCichon, Sven-
dc.contributor.authorGrigoroiu-Serbanescu, Maria-
dc.contributor.authorHauser, Joanna-
dc.contributor.authorLissowska, Jolanta-
dc.contributor.authorMayoral, Fermin-
dc.contributor.authorMüller-Myhsok, Bertram-
dc.contributor.authorŚwiątkowska, Beata-
dc.contributor.authorSchulze, Thomas G-
dc.contributor.authorNöthen, Markus M-
dc.contributor.authorRietschel, Marcella-
dc.contributor.authorKelsoe, John-
dc.contributor.authorLeboyer, Marion-
dc.contributor.authorJamain, Stéphane-
dc.contributor.authorEtain, Bruno-
dc.contributor.authorBellivier, Frank-
dc.contributor.authorVincent, John B-
dc.contributor.authorAlda, Martin-
dc.contributor.authorO'Donovan, Claire-
dc.contributor.authorCervantes, Pablo-
dc.contributor.authorBiernacka, Joanna M-
dc.contributor.authorFrye, Mark-
dc.contributor.authorMcElroy, Susan L-
dc.contributor.authorScott, Laura J-
dc.contributor.authorStahl, Eli A-
dc.contributor.authorLandén, Mikael-
dc.contributor.authorHamshere, Marian L-
dc.contributor.authorSmeland, Olav B-
dc.contributor.authorDjurovic, Srdjan-
dc.contributor.authorVaaler, Arne E-
dc.contributor.authorAndreassen, Ole A-
dc.contributor.authorBaune, Bernhard T-
dc.contributor.authorAir, Tracy-
dc.contributor.authorPreisig, Martin-
dc.contributor.authorUher, Rudolf-
dc.contributor.authorLevinson, Douglas F-
dc.contributor.authorWeissman, Myrna M-
dc.contributor.authorPotash, James B-
dc.contributor.authorShi, Jianxin-
dc.contributor.authorKnowles, James A-
dc.contributor.authorPerlis, Roy H-
dc.contributor.authorLucae, Susanne-
dc.contributor.authorBoomsma, Dorret I-
dc.contributor.authorPenninx, Brenda W J H-
dc.contributor.authorHottenga, Jouke-Jan-
dc.contributor.authorde Geus, Eco J C-
dc.contributor.authorWillemsen, Gonneke-
dc.contributor.authorMilaneschi, Yuri-
dc.contributor.authorTiemeier, Henning-
dc.contributor.authorGrabe, Hans J-
dc.contributor.authorTeumer, Alexander-
dc.contributor.authorVan der Auwera, Sandra-
dc.contributor.authorVölker, Uwe-
dc.contributor.authorHamilton, Steven P-
dc.contributor.authorMagnusson, Patrik K E-
dc.contributor.authorViktorin, Alexander-
dc.contributor.authorMehta, Divya-
dc.contributor.authorMullins, Niamh-
dc.contributor.authorAdams, Mark J-
dc.contributor.authorBreen, Gerome-
dc.contributor.authorMcIntosh, Andrew M-
dc.contributor.authorLewis, Cathryn M-
dc.contributor.authorHougaard, David M-
dc.contributor.authorNordentoft, Merete-
dc.contributor.authorMors, Ole-
dc.contributor.authorMortensen, Preben B-
dc.contributor.authorWerge, Thomas-
dc.contributor.authorAls, Thomas D-
dc.contributor.authorBørglum, Anders D-
dc.contributor.authorPetryshen, Tracey L-
dc.contributor.authorSmoller, Jordan W-
dc.contributor.authorGoldstein, Jill M-
dc.date2021-
dc.date.accessioned2022-01-10T04:56:25Z-
dc.date.available2022-01-10T04:56:25Z-
dc.date.issued2022-01-01-
dc.identifier.citationBiological Psychiatry 2022; 91(1): 102-117en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/28577-
dc.description.abstractSex differences in incidence and/or presentation of schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence for shared genetic risk and sex differences in brain abnormalities across disorders suggest possible shared sex-dependent genetic risk. We conducted the largest to date genome-wide genotype-by-sex (G×S) interaction of risk for these disorders using 85,735 cases (33,403 SCZ, 19,924 BIP, and 32,408 MDD) and 109,946 controls from the PGC (Psychiatric Genomics Consortium) and iPSYCH. Across disorders, genome-wide significant single nucleotide polymorphism-by-sex interaction was detected for a locus encompassing NKAIN2 (rs117780815, p = 3.2 × 10-8), which interacts with sodium/potassium-transporting ATPase (adenosine triphosphatase) enzymes, implicating neuronal excitability. Three additional loci showed evidence (p < 1 × 10-6) for cross-disorder G×S interaction (rs7302529, p = 1.6 × 10-7; rs73033497, p = 8.8 × 10-7; rs7914279, p = 6.4 × 10-7), implicating various functions. Gene-based analyses identified G×S interaction across disorders (p = 8.97 × 10-7) with transcriptional inhibitor SLTM. Most significant in SCZ was a MOCOS gene locus (rs11665282, p = 1.5 × 10-7), implicating vascular endothelial cells. Secondary analysis of the PGC-SCZ dataset detected an interaction (rs13265509, p = 1.1 × 10-7) in a locus containing IDO2, a kynurenine pathway enzyme with immunoregulatory functions implicated in SCZ, BIP, and MDD. Pathway enrichment analysis detected significant G×S interaction of genes regulating vascular endothelial growth factor receptor signaling in MDD (false discovery rate-corrected p < .05). In the largest genome-wide G×S analysis of mood and psychotic disorders to date, there was substantial genetic overlap between the sexes. However, significant sex-dependent effects were enriched for genes related to neuronal development and immune and vascular functions across and within SCZ, BIP, and MDD at the variant, gene, and pathway levels.en
dc.language.isoeng
dc.subjectBipolar disorderen
dc.subjectGenome-wide association studyen
dc.subjectGenotype-by-sex interactionen
dc.subjectMajor depressive disorderen
dc.subjectSchizophreniaen
dc.subjectSex differencesen
dc.titleSex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders.en
dc.typeJournal Articleen
dc.identifier.journaltitleBiological Psychiatryen
dc.identifier.affiliationDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands..en
dc.identifier.affiliationPsychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts..en
dc.identifier.affiliationDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts..en
dc.identifier.affiliationDepartment of Biomedicine, Aarhus University, Aarhus, Denmark..en
dc.identifier.affiliationThe Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen, Denmark..en
dc.identifier.affiliationCenter for Genome Analysis and Personalized Medicine, Aarhus, Denmark..en
dc.identifier.affiliationBioinformatics Research Centre (BiRC), Aarhus, Denmark..en
dc.identifier.affiliationPsychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts..en
dc.identifier.affiliationBiogen Inc., Cambridge, Massachusetts..en
dc.identifier.affiliationStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts..en
dc.identifier.affiliationDepartments of Neurology and Genetics, Yale School of Medicine, New Haven, Connecticut..en
dc.identifier.affiliationInnovation Center on Sex Differences in Medicine (ICON), Massachusetts General Hospital, Boston, Massachusetts..en
dc.identifier.affiliationDepartment of Biomedical Sciences, Colorado State University, Fort Collins, Colorado..en
dc.identifier.affiliationUniversity of Aberdeen, Institute of Medical Sciences, Aberdeen, United Kingdom..en
dc.identifier.affiliationThe Feinstein Institute for Medical Research, Manhasset, New York..en
dc.identifier.affiliationThe Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York..en
dc.identifier.affiliationThe Zucker Hillside Hospital, Glen Oaks, New York..en
dc.identifier.affiliationQueensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia..en
dc.identifier.affiliationQueensland Centre for Mental Health Research, University of Queensland, Brisbane, Queensland, Australia..en
dc.identifier.affiliationQueensland Centre for Mental Health Research, The Park - Centre for Mental Health, Wacol, Queensland, Australia..en
dc.identifier.affiliationSchizophrenia Research Institute, Sydney, New South Wales, Australia..en
dc.identifier.affiliationSchool of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia..en
dc.identifier.affiliationPriority Centre for Translational Neuroscience and Mental Health, University of Newcastle, Newcastle, New South Wales, Australia..en
dc.identifier.affiliationSchool of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia..en
dc.identifier.affiliationPriority Centre for Translational Neuroscience and Mental Health, University of Newcastle, Newcastle, New South Wales, Australia..en
dc.identifier.affiliationSchizophrenia Research Institute, Sydney, New South Wales, Australia..en
dc.identifier.affiliationPriority Centre for Translational Neuroscience and Mental Health, University of Newcastle, Newcastle, New South Wales, Australia..en
dc.identifier.affiliationMRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom..en
dc.identifier.affiliationDepartments of Genetics and Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina..en
dc.identifier.affiliationDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden..en
dc.identifier.affiliationNeuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Dublin, Ireland..en
dc.identifier.affiliationVirginia Institute for Psychiatric and Behavioral Genetics, Departments of Psychiatry and Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia..en
dc.identifier.affiliationBroad Institute of MIT and Harvard, Cambridge, Massachusetts..en
dc.identifier.affiliationMedical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts..en
dc.identifier.affiliationInstitute of Genomics, University of Tartu, Tartu, Estonia..en
dc.identifier.affiliationDepartment of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm, Sweden..en
dc.identifier.affiliationNorwegian Centre for Mental Disorders Research (NORMENT), KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway..en
dc.identifier.affiliationPsychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts..en
dc.identifier.affiliationInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland..en
dc.identifier.affiliationDepartment of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany..en
dc.identifier.affiliationDepartment of Psychiatry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR China..en
dc.identifier.affiliationState Key Laboratory for Brain and Cognitive Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR China..en
dc.identifier.affiliationCentre for Genomic Sciences, The University of Hong Kong, Hong Kong, SAR China..en
dc.identifier.affiliationDepartment of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan..en
dc.identifier.affiliationLieber Institute for Brain Development, Baltimore, Maryland..en
dc.identifier.affiliationDepartments of Psychiatry, Neurology, Neuroscience and Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland..en
dc.identifier.affiliationDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois..en
dc.identifier.affiliationDepartment of Psychiatry and Behavioral Sciences, North Shore University Health System, Evanston, Illinois..en
dc.identifier.affiliationDepartments of Human Genetics and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York..en
dc.identifier.affiliationDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York..en
dc.identifier.affiliationFriedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York..en
dc.identifier.affiliationDepartment of Psychiatry, University of Halle, Halle, Germany..en
dc.identifier.affiliationDepartment of Psychiatry, University of Munich, Munich, Germany..en
dc.identifier.affiliationMental Health Neuroscience Research Department, Division of Psychiatry, Faculty of Brain Sciences, University College London, London, United Kingdom..en
dc.identifier.affiliationInstitute of Psychiatry, King's College London, London, United Kingdom..en
dc.identifier.affiliationInstitute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, New York..en
dc.identifier.affiliationDepartment of Psychiatry and Zilkha Neurogenetics Institute, Keck School of Medicine at University of Southern California, Los Angeles, California..en
dc.identifier.affiliationResearch Division and Department of General Psychiatry, Institute of Mental Health, Singapore, Singapore..en
dc.identifier.affiliationDuke-National University of Singapore Graduate Medical School, Singapore..en
dc.identifier.affiliationNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway..en
dc.identifier.affiliationCenter for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway; Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, Oslo, Norway..en
dc.identifier.affiliationUniversity Medical Center Utrecht, Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, Utrecht, the Netherlands..en
dc.identifier.affiliationDepartment of Human Genetics, University of California, Los Angeles, California..en
dc.identifier.affiliationDavid Geffen School of Medicine, and Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California..en
dc.identifier.affiliationMolecular Psychiatry Laboratory, Division of Psychiatry, University College London, London, United Kingdom..en
dc.identifier.affiliationDepartment of Clinical Sciences, Psychiatry, Umeå University Medical Faculty, Umeå, Sweden..en
dc.identifier.affiliationSchool of Psychology, University of Queensland, Brisbane, Queensland, Australia..en
dc.identifier.affiliationGenetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia..en
dc.identifier.affiliationNeuroscience Research Australia, Sydney, New South Wales, Australia..en
dc.identifier.affiliationSchool of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia..en
dc.identifier.affiliationSchool of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia..en
dc.identifier.affiliationCentre for Human Genetics, University of Marburg, Marburg, Germany..en
dc.identifier.affiliationInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany..en
dc.identifier.affiliationDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Duisburg, Germany..en
dc.identifier.affiliationInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany..en
dc.identifier.affiliationInternational Max Planck Research School for Translational Psychiatry (IMPRS-TP), Munich, Germany..en
dc.identifier.affiliationISGlobal, Barcelona, Spain..en
dc.identifier.affiliationMental Health Department, University Regional Hospital, Biomedical Research Institute of Málaga (IBIMA), Málaga, Spain..en
dc.identifier.affiliationDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany..en
dc.identifier.affiliationDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany..en
dc.identifier.affiliationInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany..en
dc.identifier.affiliationInstitute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany..en
dc.identifier.affiliationDepartment of Biomedicine, University of Basel, Basel, Switzerland..en
dc.identifier.affiliationInstitute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland..en
dc.identifier.affiliationBiometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania..en
dc.identifier.affiliationDepartment of Psychiatry, Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland..en
dc.identifier.affiliationCancer Epidemiology and Prevention, M. Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland..en
dc.identifier.affiliationUniversity of Liverpool, Liverpool, United Kingdom; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany..en
dc.identifier.affiliationMunich Cluster for Systems Neurology (SyNergy), Munich, Germany..en
dc.identifier.affiliationDepartment of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland..en
dc.identifier.affiliationDepartment of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, New York..en
dc.identifier.affiliationDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland..en
dc.identifier.affiliationInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany..en
dc.identifier.affiliationDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany..en
dc.identifier.affiliationDepartment of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany..en
dc.identifier.affiliationInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany..en
dc.identifier.affiliationDepartment of Psychiatry, University of California San Diego, La Jolla, California..en
dc.identifier.affiliationFaculté de Médecine, Université Paris Est, Créteil, France..en
dc.identifier.affiliationDepartment of Psychiatry and Addiction Medicine, Assistance Publique - Hôpitaux de Paris, Paris, France..en
dc.identifier.affiliationInstitut national de la santé et de la recherche médicale (INSERM), Paris, France..en
dc.identifier.affiliationFaculté de Médecine, Université Paris Est, Créteil, France; INSERM U955, Psychiatrie Translationnelle, Créteil, France..en
dc.identifier.affiliationCentre for Affective Disorders, Institute of Psychiatry, Psychology and Neuroscience, London, United Kingdom..en
dc.identifier.affiliationDepartment of Psychiatry and Addiction Medicine, Assistance Publique - Hôpitaux de Paris, Paris, France..en
dc.identifier.affiliationUMR-S1144 Team 1 Biomarkers of relapse and therapeutic response in addiction and mood disorders, INSERM, Paris, France..en
dc.identifier.affiliationPsychiatry, Université Paris Diderot, Paris, France..en
dc.identifier.affiliationUMR-S1144 Team 1 Biomarkers of relapse and therapeutic response in addiction and mood disorders, INSERM, Paris, France..en
dc.identifier.affiliationParis Bipolar and TRD Expert Centres, FondaMental Foundation, Paris, France..en
dc.identifier.affiliationCentre for Addiction and Mental Health, Toronto, Ontario, Canada..en
dc.identifier.affiliationDepartment of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada..en
dc.identifier.affiliationNational Institute of Mental Health, Klecany, Czech Republic..en
dc.identifier.affiliationDepartment of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada..en
dc.identifier.affiliationDepartment of Psychiatry, Mood Disorders Program, McGill University Health Center, Montréal, Québec, Canada..en
dc.identifier.affiliationDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota..en
dc.identifier.affiliationDepartment of Psychiatry & Psychology, Mayo Clinic, Rochester, Minnesota..en
dc.identifier.affiliationResearch Institute, Lindner Center of HOPE, Mason, Ohio..en
dc.identifier.affiliationCenter for Statistical Genetics and Department of Biostatistics, University of Michigan, Ann Arbor, Michigan..en
dc.identifier.affiliationMedical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts..en
dc.identifier.affiliationDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York..en
dc.identifier.affiliationDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York..en
dc.identifier.affiliationDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden..en
dc.identifier.affiliationInstitute of Neuroscience and Physiology, the Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden..en
dc.identifier.affiliationDepartment of Medical Genetics, Oslo University Hospital, Oslo, Norway..en
dc.identifier.affiliationNORMENT Centre, Department of Clinical Science, University of Bergen, Bergen, Norway..en
dc.identifier.affiliationDepartment of Mental Health, Norwegian University of Science and Technology - NTNU, Trondheim, Norway..en
dc.identifier.affiliationDepartment of Psychiatry, St Olavs' University Hospital, Trondheim, Norway..en
dc.identifier.affiliationDepartment of Psychiatry, Melbourne Medical School, University of Melbourne, Melbourne, Victoria, Australia..en
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Healthen
dc.identifier.affiliationDepartment of Psychiatry, University of Münster, Münster, Germany..en
dc.identifier.affiliationDiscipline of Psychiatry, The University of Adelaide, Adelaide, South Austrlalia, Australia..en
dc.identifier.affiliationDepartment of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland..en
dc.identifier.affiliationPsychiatry & Behavioral Sciences, Stanford University, Stanford, California..en
dc.identifier.affiliationDepartment of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York..en
dc.identifier.affiliationDivision of Translational Epidemiology, New York State Psychiatric Institute, New York, New York..en
dc.identifier.affiliationDepartment of Psychiatry, University of Iowa, Iowa City, Iowa.en
dc.identifier.affiliationDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland..en
dc.identifier.affiliationPsychiatry & The Behavioral Sciences, University of Southern California, Los Angeles, California..en
dc.identifier.affiliationPsychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts..en
dc.identifier.affiliationDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts..en
dc.identifier.affiliationDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany..en
dc.identifier.affiliationMax Planck Institute of Psychiatry, Munich, Germany..en
dc.identifier.affiliationDepartment of Biological Psychology/Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands..en
dc.identifier.affiliationAmsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, the Netherlands..en
dc.identifier.affiliationDepartment of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, the Netherlands..en
dc.identifier.affiliationChild and Adolescent Psychiatry, Erasmus Medical Center, Rotterdam, the Netherlands..en
dc.identifier.affiliationDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany..en
dc.identifier.affiliationInstitute of Community Medicine, University Medicine Greifswald, Greifswald, Germany..en
dc.identifier.affiliationInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany..en
dc.identifier.affiliationKaiser Permanente Northern California, San Francisco, California..en
dc.identifier.affiliationDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden..en
dc.identifier.affiliationSchool of Psychology and Counseling, Queensland University of Technology, Brisbane, Queensland, Australia..en
dc.identifier.affiliationDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York..en
dc.identifier.affiliationDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York..en
dc.identifier.affiliationSocial, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom..en
dc.identifier.affiliationDivision of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom..en
dc.identifier.affiliationNIHR Maudsley Biomedical Research Centre, King's College London, London, United Kingdom..en
dc.identifier.affiliationCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom..en
dc.identifier.affiliationThe Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen, Denmark..en
dc.identifier.affiliationDepartment of Medical & Molecular Genetics, King's College London, London, United Kingdom..en
dc.identifier.affiliationCenter for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark..en
dc.identifier.affiliationCopenhagen Mental Health Center, Mental Health Services Capital Region of Denmark Copenhagen, Copenhagen, Denmark..en
dc.identifier.affiliationDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark..en
dc.identifier.affiliationPsychosis Research Unit, Aarhus University Hospital, Risskov, Denmark..en
dc.identifier.affiliationCentre for Integrative Sequencing (iSEQ), Aarhus University, Aarhus, Denmark..en
dc.identifier.affiliationNational Centre for Register-Based Research (NCCR), Aarhus University, Aarhus, Denmark..en
dc.identifier.affiliationCentre for Integrated Register-based Research (CIRRAU), Aarhus University, Aarhus, Denmark..en
dc.identifier.affiliationInstitute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark..en
dc.identifier.affiliationDepartment of Biomedicine, Aarhus University, Aarhus, Denmark..en
dc.identifier.affiliationCenter for Genome Analysis and Personalized Medicine, Aarhus, Denmark..en
dc.identifier.affiliationPsychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts..en
dc.identifier.affiliationDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts..en
dc.identifier.affiliationConcert Pharmaceuticals, Inc., Lexington, Massachusetts..en
dc.identifier.affiliationInnovation Center on Sex Differences in Medicine (ICON), Massachusetts General Hospital, Boston, Massachusetts..en
dc.identifier.affiliationDepartment of Psychiatry and Vincent Department of Obstetrics, Gynecology & Reproductive Biology, Massachusetts General Hospital, Boston, Massachusetts..en
dc.identifier.affiliationMGH-MIT-HMS Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts..en
dc.identifier.affiliationDepartments of Psychiatry and Medicine, Harvard Medical School, Boston, Massachusetts..en
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/34099189/en
dc.identifier.doi10.1016/j.biopsych.2021.02.972en
dc.type.contentTexten
dc.identifier.orcid0000-0001-6548-426Xen
dc.identifier.orcid0000-0001-9554-3953en
dc.identifier.pubmedid34099189
local.name.researcherKelly, Brian D
item.languageiso639-1en-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptUrology-
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