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https://ahro.austin.org.au/austinjspui/handle/1/28236| Title: | Smaller spared subcortical nuclei are associated with worse post-stroke sensorimotor outcomes in 28 cohorts worldwide. | Austin Authors: | Liew, Sook-Lei;Zavaliangos-Petropulu, Artemis;Schweighofer, Nicolas;Jahanshad, Neda;Lang, Catherine E;Lohse, Keith R;Banaj, Nerisa;Barisano, Giuseppe;Baugh, Lee A;Bhattacharya, Anup K;Bigjahan, Bavrina;Borich, Michael R;Boyd, Lara A;Brodtmann, Amy ;Buetefisch, Cathrin M;Byblow, Winston D;Cassidy, Jessica M;Charalambous, Charalambos C;Ciullo, Valentina;Conforto, Adriana B;Craddock, Richard C;Dula, Adrienne N;Egorova, Natalia;Feng, Wuwei;Fercho, Kelene A;Gregory, Chris M;Hanlon, Colleen A;Hayward, Kathryn S ;Holguin, Jess A;Hordacre, Brenton;Hwang, Darryl H;Kautz, Steven A;Khlif, Mohamed Salah;Kim, Bokkyu;Kim, Hosung;Kuceyeski, Amy;Lo, Bethany;Liu, Jingchun;Lin, David;Lotze, Martin;MacIntosh, Bradley J;Margetis, John L;Mohamed, Feroze B;Nordvik, Jan Egil;Petoe, Matthew A;Piras, Fabrizio;Raju, Sharmila;Ramos-Murguialday, Ander;Revill, Kate P;Roberts, Pamela;Robertson, Andrew D;Schambra, Heidi M;Seo, Na Jin;Shiroishi, Mark S;Soekadar, Surjo R;Spalletta, Gianfranco;Stinear, Cathy M;Suri, Anisha;Tang, Wai Kwong;Thielman, Gregory T;Thijs, Vincent N ;Vecchio, Daniela;Ward, Nick S;Westlye, Lars T;Winstein, Carolee J;Wittenberg, George F;Wong, Kristin A;Yu, Chunshui;Wolf, Steven L;Cramer, Steven C;Thompson, Paul M | Affiliation: | California Rehabilitation Institute, Los Angeles, CA, USA Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, USA Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA Departments of Physical Therapy, Washington University School of Medicine, St. Louis, MO, USA Department of Occupational Therapy, Washington University School of Medicine, St. Louis, MO, USA Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA Laboratory of Neuro Imaging, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA Sioux Falls VA Health Care System, Sioux Falls, SD, USA Center for Brain and Behavior Research, Vermillion, SD, USA Sanford Research, Sioux Falls, SD, USA Department of Rehabilitation Medicine, Emory University, Atlanta, GA, USA Department of Neurology, School of Medicine, Emory University, Atlanta, GA, USA Department of Radiology, Emory University, Atlanta, GA, USA Department of Basic and Clinical Sciences, University of Nicosia Medical School, Nicosia, Cyprus Center for Neuroscience and Integrative Brain Research (CENIBRE), University of Nicosia Medical School, Nicosia, Cyprus Innovation, IMPlementation and Clinical Translation (IIMPACT) in Health, Allied Health and Human Performance, University of South Australia, Adelaide, SA, Australia The Florey Institute of Neuroscience and Mental Health Eastern Cognitive Disorders Clinic, Monash University, Melbourne, VIC, Australia Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, VIC, Australia Department of Physiotherapy, University of Melbourne, Heidelberg, VIC, Australia NHMRC CRE in Stroke Rehabilitation and Brain Recovery, University of Melbourne, Heidelberg, VIC, Australia Neurology Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil Hospital Israelita Albert Einstein, São Paulo, SP, Brazil Civil Aerospace Medical Institute, US Federal Aviation Administration, Oklahoma City, OK, USA Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA Cancer Biology, Wake Forest School of Medicine, Winston Salem, NC, USA College of Health Professions, Medical University of South Carolina, Charleston, SC, USA Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA Department of Health Sciences & Research, Medical University of South Carolina, Charleston, SC, USA Ralph H. Johnson VA Medical Center, Charleston, SC, USA Hurvitz Brain Sciences, Sunnybrook Research Institute, Toronto, ON, Canada Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada Bionics Institute, Melbourne, VIC, Australia Department of Medicine and Centre for Brain Research, University of Auckland, Auckland, New Zealand TECNALIA, Basque Research and Technology Alliance (BRTA), Health Division, San Sebastian Donostia, Spain Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Tübingen, Germany Department of Physical Medicine and Rehabilitation, Cedars-Sinai, Los Angeles, CA, USA California Rehabilitation Institute, Los Angeles, CA, USA Canadian Partnership for Stroke Recovery, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada Department of Kinesiology, University of Waterloo, Waterloo, ON, Canada Ralph H. Johnson VA Medical Center, Charleston, SC, USA Department of Rehabilitation Sciences, Medical University of South Carolina, Charleston, SC, USA Department of Psychology, University of Oslo, Oslo, Norway NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway Biokinesiology and Physical Therapy, Ostrow School of Medicine, University of Southern California, Los Angeles, CA, USA Department of Neurology, University of California, Los Angeles, Los Angeles, CA, USA Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA Neurology, Department of Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, USA Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China Division of Physical Therapy Education, Department of Rehabilitation Medicine, Emory University School of Medicine, Atlanta, GA, USA Division of Physical Therapy Education, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA Division of Physical Therapy Education, Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, USA Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Health Care System, Decatur, GA, USA Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy Division of Neuropsychiatry, Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA Chan Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles, CA, USA Keck School of Medicine, Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, USA Biokinesiology and Physical Therapy, Ostrow School of Medicine, University of Southern California, Los Angeles, CA, USA Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA Department of Health and Kinesiology, University of Utah, Salt Lake City, UT, USA Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA Department of Rehabilitation Medicine, Emory University, Atlanta, GA, USA Department of Physical Therapy & the Djavad Mowafaghian Centre for Brain Health, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada Department of Exercise Sciences and Centre for Brain Research, University of Auckland, Auckland, New Zealand Allied Health Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy Department of Neurology, Dell Medical School, University of Texas at Austin, Austin, TX, USA Department of Health Sciences & Research, Medical University of South Carolina, Charleston, SC, USA Chan Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles, CA, USA Department of Physical Therapy Education, College of Health Professions, SUNY Upstate Medical University, Syracuse, NY, USA Keck School of Medicine, Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, USA Department of Radiology, Weill Cornell Medicine, New York, NY, USA Chan Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles, CA, USA Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA Department of Diagnostic Radiology, University Medicine Greifswald, Greifswald, Germany Chan Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles, CA, USA Jefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USA CatoSenteret Rehabilitation Center, Son, Norway Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy Department of Neurology, New York University Langone, New York, NY, USA Facility for Education and Research in Neuroscience, Emory University, Atlanta, GA, USA Department of Neurology, New York University Langone, New York, NY, USA Clinical Neurotechnology Laboratory, Department of Psychiatry and Psychotherapy, Charité - University Medicine Berlin, Berlin, Germany Department of Medicine, University of Auckland, Auckland, New Zealand Department of Electrical and Computer Engineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA Department of Psychiatry, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong, China Department of Physical Therapy and Neuroscience, University of the Sciences, Philadelphia, PA, USA Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy UCL Queen Square Institute of Neurology, London, UK Department of Physical Medicine & Rehabilitation, Dell Medical School, University of Texas at Austin, Austin, TX, USA Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA |
Issue Date: | 27-Oct-2021 | Date: | 2021 | Publication information: | Brain Communications 2021; 3(4): fcab254 | Abstract: | Up to two-thirds of stroke survivors experience persistent sensorimotor impairments. Recovery relies on the integrity of spared brain areas to compensate for damaged tissue. Deep grey matter structures play a critical role in the control and regulation of sensorimotor circuits. The goal of this work is to identify associations between volumes of spared subcortical nuclei and sensorimotor behaviour at different timepoints after stroke. We pooled high-resolution T1-weighted MRI brain scans and behavioural data in 828 individuals with unilateral stroke from 28 cohorts worldwide. Cross-sectional analyses using linear mixed-effects models related post-stroke sensorimotor behaviour to non-lesioned subcortical volumes (Bonferroni-corrected, P < 0.004). We tested subacute (≤90 days) and chronic (≥180 days) stroke subgroups separately, with exploratory analyses in early stroke (≤21 days) and across all time. Sub-analyses in chronic stroke were also performed based on class of sensorimotor deficits (impairment, activity limitations) and side of lesioned hemisphere. Worse sensorimotor behaviour was associated with a smaller ipsilesional thalamic volume in both early (n = 179; d = 0.68) and subacute (n = 274, d = 0.46) stroke. In chronic stroke (n = 404), worse sensorimotor behaviour was associated with smaller ipsilesional putamen (d = 0.52) and nucleus accumbens (d = 0.39) volumes, and a larger ipsilesional lateral ventricle (d = -0.42). Worse chronic sensorimotor impairment specifically (measured by the Fugl-Meyer Assessment; n = 256) was associated with smaller ipsilesional putamen (d = 0.72) and larger lateral ventricle (d = -0.41) volumes, while several measures of activity limitations (n = 116) showed no significant relationships. In the full cohort across all time (n = 828), sensorimotor behaviour was associated with the volumes of the ipsilesional nucleus accumbens (d = 0.23), putamen (d = 0.33), thalamus (d = 0.33) and lateral ventricle (d = -0.23). We demonstrate significant relationships between post-stroke sensorimotor behaviour and reduced volumes of deep grey matter structures that were spared by stroke, which differ by time and class of sensorimotor measure. These findings provide additional insight into how different cortico-thalamo-striatal circuits support post-stroke sensorimotor outcomes. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/28236 | DOI: | 10.1093/braincomms/fcab254 | ORCID: | 0000-0001-5935-4215 0000-0001-5598-1369 0000-0001-8145-8176 0000-0002-2828-4549 0000-0003-3469-0399 0000-0002-1547-1839 0000-0002-9244-2900 0000-0001-5240-3264 0000-0002-7129-6684 0000-0002-1111-9176 0000-0002-6575-9849 0000-0003-4519-4956 0000-0003-0981-648X 0000-0001-5456-5056 0000-0002-9095-9877 0000-0001-6446-5905 0000-0002-9404-1959 0000-0001-8644-956X |
Journal: | Brain Communications | PubMed URL: | 34805997 | Type: | Journal Article | Subjects: | MRI rehabilitation sensorimotor behaviour stroke subcortical volumes |
| Appears in Collections: | Journal articles |
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