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https://ahro.austin.org.au/austinjspui/handle/1/27966| Title: | Androgen receptor CAG repeat length as a moderator of the relationship between free testosterone levels and cognition. | Austin Authors: | Tan, Sherilyn;Porter, Tenielle;Bucks, Romola S;Weinborn, Michael;Milicic, Lidija;Brown, Ailsa;Rainey-Smith, Stephanie R;Taddei, Kevin;Ames, David;Masters, Colin L ;Maruff, Paul;Savage, Greg;Rowe, Christopher C ;Villemagne, Victor L ;Brown, Belinda;Sohrabi, Hamid R;Laws, Simon M;Martins, Ralph N | Affiliation: | School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia, Australia CogState Ltd, Melbourne, Victoria, Australia Molecular Imaging and Therapy School of Psychological Science, University of Western Australia, Nedlands, Western Australia, Australia Australian Alzheimer's Research Foundation, Ralph and Patricia Sarich Neuroscience Research Institute, Nedlands, Western Australia, Australia Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia Centre for Healthy Ageing, College of Science, Health, Engineering and Education (SHEE), Murdoch University, Murdoch, Western Australia, Australia Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia Centre for Precision Health, Edith Cowan University, Joondalup, Western Australia, Australia Cooperative Research Centre for Mental Health, Carlton, Victoria, Australia Department of Biomedical Sciences, Faculty of Medicine and Health Science, Macquarie University, Sydney, New South Wales, Australia Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia University of Melbourne Academic Unit for Psychiatry of Old Age, Parkville, Victoria, Australia National Ageing Research Institute (NARI), Parkville, Victoria, Australia |
Issue Date: | May-2021 | Date: | 2021-03-11 | Publication information: | Hormones and Behavior 2021; 131: 104966 | Abstract: | Age-related decrease in testosterone levels is a potential risk factor for cognitive decline in older men. However, observational studies and clinical trials have reported inconsistent results on the effects of testosterone on individual cognitive domains. Null findings may be attributed to factors that studies have yet to consider. In particular, individual variations in polyglutamine (CAG) length in the androgen receptor (AR) gene could alter androgenic activity in brain regions associated with cognitive processes including memory and executive functions. However, the role of AR CAG repeat length as a moderator of the relationship between testosterone levels and cognition has not been investigated. Therefore, we aimed to examine the relationship between baseline calculated free testosterone (cFT) levels, change in cFT levels over 18 months and CAG repeat length on cognitive performance in memory, executive function, language, attention and processing speed domains. These relationships were examined in 304 cognitively normal older male participants of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Ageing. In the attention and processing speed domain, a short CAG repeat length appears to exacerbate the effects of low baseline cFT levels that are also lower than expected at follow-up. These results highlight that individual variations in AR CAG repeat length should be considered in future studies and clinical trials that examine the complex relationship between testosterone and cognition. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/27966 | DOI: | 10.1016/j.yhbeh.2021.104966 | Journal: | Hormones and Behavior | PubMed URL: | 33714752 | Type: | Journal Article | Subjects: | Alzheimer's disease Androgen receptor Attention Cognition Executive function Language Memory Processing speed Testosterone |
| Appears in Collections: | Journal articles |
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