Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/27942
Title: Acute disseminated encephalomyelitis (ADEM) following recent Oxford/AstraZeneca COVID-19 vaccination.
Austin Authors: Permezel, Fiona ;Borojevic, Branko;Lau, Stephanie;de Boer, Hans H
Affiliation: Department of Forensic Medicine, Monash University, Southbank, VIC, Australia
Victorian Institute of Forensic Medicine, Southbank, VIC, Australia
Neurology
General Medicine
Anatomical Pathology
Issue Date: 2022
Date: 2021-11-04
Publication information: Forensic science, medicine, and pathology 2022; 18(1): 74-79
Abstract: This report describes the clinical context and autopsy findings in the first reported fatal case of acute disseminated encephalomyelitis (ADEM), developed after being vaccinated using the Oxford/AstraZeneca COVID-19 vaccine. ADEM is a rare autoimmune disease, causing demyelination in the brain and spinal cord. A wide variety of precipitating factors can trigger ADEM, and it has long been known to be a rare adverse event following some types of vaccinations. Recently, ADEM has also been associated with COVID-19 infection and (very rarely) with COVID-19 vaccination. The reports of the latter however all pertain to living patients. Our case demonstrates that ADEM should be considered in patients developing neurological symptoms post COVID-19 vaccination, although that this adverse reaction is likely to remain extremely rare. Our report further emphasizes the added value of comprehensive post mortem investigation to confirm ante mortem diagnosis and to determine vaccination safety.
URI: https://ahro.austin.org.au/austinjspui/handle/1/27942
DOI: 10.1007/s12024-021-00440-7
ORCID: 0000-0001-8564-7142
0000-0001-8590-0945
Journal: Forensic science, Medicine, and Pathology
PubMed URL: 34735684
Type: Journal Article
Subjects: ADEM
Acute disseminated encephalomyelitis
Adverse event
COVID-19
Forensic pathology
Vaccination
Appears in Collections:Journal articles

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