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https://ahro.austin.org.au/austinjspui/handle/1/27784| Title: | Urinary biomarkers to predict severe fluid overload after cardiac surgery: a pilot study. | Austin Authors: | Elitok, Saban;Isermann, Berend;Westphal, Sabine;Devarajan, Prasad;Albert, Christian;Kuppe, Hermann;Ernst, Martin;Bellomo, Rinaldo ;Haase, Michael;Haase-Fielitz, Anja | Affiliation: | Institute of Social Medicine & Health Care Systems Research, Otto von-Guericke-University Magdeburg, Leipziger Str. 44, Magdeburg, 39120, Germany Diaverum Renal Care Center, Am Neuen Garten 11, 14469 Potsdam, Germany & Diaverum AB, Hyllie Boulevard 35, Malmö, 21532, Sweden Department of Nephrology & Endocrinology, Ernst von Bergmann Hospital Potsdam, Charlottenstr. 72, Potsdam, 14467, Germany Department of Cardiology, Brandenburg Heart Center, Immanuel Hospital, Ladeburger Str. 17, Bernau, 16321, Germany Brandenburg Medical School Theodor Fontane, Fehrbelliner Str. 38, Neuruppin, 16816, Germany Faculty of Health Sciences Brandenburg, University of Potsdam, Potsdam, Germany Institute of Laboratory Medicine, Leipzig University Hospital, Paul-List-Str. 13/15, Leipzig, 04103, Germany Institute of Laboratory Medicine, Tertiary Hospital Dessau, Auenweg 38, Dessau-Roßlau, 06847, Germany Institute of Anesthesiology, German Heart Center, Augustenburger Platz 1, Berlin, 13353, Germany Department of Nephrology & Hypertension, Cincinnati Children's Hospital, 3333 Burnet Ave, Cincinnati, OH 45229, USA Medical Faculty, University Clinic for Cardiology & Angiology, Otto von-Guericke-University Magdeburg, Leipziger Str. 44, Magdeburg, 39120, Germany Medical Faculty, Otto von-Guericke-University Magdeburg, Leipziger Str. 44, Magdeburg, 39120, Germany Intensive Care Centre for Integrated Critical Care, The University of Melbourne, Melbourne, Australia |
Issue Date: | 2021 | Date: | 2021-10-21 | Publication information: | Biomarkers in medicine 2021; 15(16): 1451-1464 | Abstract: | Aim: To assess the predictive ability of urinary and plasma biomarkers and clinical routine parameters for subsequent severe fluid overload. Patients & methods: In a pilot study, we studied 100 adult patients after cardiac surgery. On intensive care unit admission, we measured biomarkers in urine (midkine, IL-6, neutrophil gelatinase-associated lipocalin [NGAL], hepcidin-25) and plasma (creatinine, urea, B-type natriuretic peptide, lactate, C-reactive protein, leukocytes, IL-6, NGAL, hepcidin-25) to predict postoperative severe fluid overload. Results: Urinary midkine, IL-6, NGAL and hepcidin-25 (all AUCs ≥0.79) predicted postoperative severe fluid overload (N = 5 patients). Urinary NGAL/hepcidin-25 ratio (AUC 0.867) predicted postoperative severe fluid overload after adjustment to EuroScore and need for norepinephrine on surgery day (odds ratio: 2.4). Conclusion: Urinary biomarkers on intensive care unit admission might be helpful to predict subsequent severe fluid overload after cardiac surgery. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/27784 | DOI: | 10.2217/bmm-2021-0283 | ORCID: | 0000-0002-1195-6871 0000-0003-0714-6160 0000-0002-5846-3345 0000-0002-7847-8552 0000-0002-6956-9962 0000-0003-3401-6935 0000-0002-1650-8939 0000-0001-8212-7416 0000-0001-6881-2249 |
Journal: | Biomarkers in Medicine | PubMed URL: | 34672680 | Type: | Journal Article | Subjects: | IL-6 NGAL/hepcidin ratio biomarker cardiac surgery cardiopulmonary bypass cardiorenal syndrome fluid overload heart kidney midkine |
| Appears in Collections: | Journal articles |
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