Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/26000
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dc.contributor.authorJeganathan, Vishnu-
dc.contributor.authorRautela, Linda-
dc.contributor.authorConti, Simon-
dc.contributor.authorSaravanan, Krisha-
dc.contributor.authorRigoni, Alyssa-
dc.contributor.authorGraco, Marnie-
dc.contributor.authorHannan, Liam M-
dc.contributor.authorHoward, Mark E-
dc.contributor.authorBerlowitz, David J-
dc.date2021-03-
dc.date.accessioned2021-03-09T05:05:00Z-
dc.date.available2021-03-09T05:05:00Z-
dc.date.issued2021-03-
dc.identifier.citationBMJ Open Respiratory Research 2021; 8(1): e000824en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/26000-
dc.description.abstractDespite increasing capacity to remotely monitor non-invasive ventilation (NIV), how remote data varies from day to day and person to person is poorly described. Single-centre, 2-month, prospective study of clinically stable adults on long-term NIV which aimed to document NIV-device variability. Participants were switched to a ventilator with tele-monitoring capabilities. Ventilation settings and masking were not altered. Raw, extensible markup language data files were provided directly from Philips Respironics (EncoreAnywhere). A nested analysis of variance was conducted on each ventilator variable to apportion the relative variation between and within participants. Twenty-nine people were recruited (four withdrew, one had insufficient data for analyses; 1364 days of data). Mean age was 54.0 years (SD 18.4), 58.3% male with body mass index of 37.0 kg/m2 (13.7). Mean adherence was 8.53 (2.23) hours/day and all participants had adherence >4 hours/day. Variance in ventilator-derived indices was predominantly driven by differences between participants; usage (61% between vs 39% within), Apnoea-Hypopnoea Index (71% vs 29%), unintentional (64% vs 36%) and total leak (83% vs 17%), tidal volume (93% vs 7%), minute ventilation (92% vs 8%), respiratory rate (92% vs 8%) and percentage of triggered breaths (93% vs 7%). In this clinically stable cohort, all device-derived indices were more varied between users than the day-to-day variation within individuals. We speculate that normative ranges and thresholds for clinical intervention need to be individualised, and further research is necessary to determine the clinically important relationships between clinician targets for therapy and patient-reported outcomes.en
dc.language.isoeng
dc.subjectassisted ventilationen
dc.subjectclinical epidemiologyen
dc.subjectnon invasive ventilationen
dc.titleTypical within and between person variability in non-invasive ventilator derived variables among clinically stable, long-term users.en
dc.typeJournal Articleen_US
dc.identifier.journaltitleBMJ Open Respiratory Researchen
dc.identifier.affiliationRespiratory and Sleep Medicineen
dc.identifier.affiliationPhysiotherapyen
dc.identifier.affiliationInstitute for Breathing and Sleepen
dc.identifier.affiliationDepartment of Physiotherapy, The University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationRespiratory Medicine, Northern Health, Epping, Victoria, Australiaen
dc.identifier.doi10.1136/bmjresp-2020-000824en
dc.type.contentTexten_US
dc.identifier.orcid0000-0003-2543-8722en
dc.identifier.pubmedid33664121
local.name.researcherBerlowitz, David J
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptRespiratory and Sleep Medicine-
crisitem.author.deptInstitute for Breathing and Sleep-
crisitem.author.deptPhysiotherapy-
crisitem.author.deptInstitute for Breathing and Sleep-
crisitem.author.deptInstitute for Breathing and Sleep-
crisitem.author.deptInstitute for Breathing and Sleep-
crisitem.author.deptPhysiotherapy-
crisitem.author.deptInstitute for Breathing and Sleep-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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