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https://ahro.austin.org.au/austinjspui/handle/1/25925| Title: | Prognostic value of acute cerebrospinal fluid abnormalities in antibody-positive autoimmune encephalitis. | Austin Authors: | Broadley, James;Wesselingh, Robb;Seneviratne, Udaya;Kyndt, Chris;Beech, Paul;Buzzard, Katherine;Nesbitt, Cassie;D'souza, Wendyl;Brodtmann, Amy ;Macdonell, Richard A L ;Kalincik, Tomas;Butzkueven, Helmut;O'Brien, Terence J;Monif, Mastura | Affiliation: | Department of Physiology, The University of Melbourne, Melbourne, Australia Department of Radiology, Monash Health, Melbourne, Australia Department of Neuroscience, Barwon Health, Geelong, Australia Department of Medicine, St Vincent's Hospital, University of Melbourne, Melbourne, Australia Department of Neuroscience, Monash University, Melbourne, Australia Department of Neurology, Alfred Health, Melbourne, Australia Department of Medicine, The University of Melbourne, Melbourne, Australia CORe, The University of Melbourne, Melbourne, Australia Department of Neurology, Melbourne Health, Melbourne, Australia Neurology Department of Neurosciences, Eastern Health, Melbourne, Australia Department of Neuroscience, Monash Health, Melbourne, Australia Department of Radiology, Alfred Health, Melbourne, Australia |
Issue Date: | 15-Apr-2021 | Date: | 2021-01-30 | Publication information: | Journal of Neuroimmunology 2021; 353: 577508 | Abstract: | To examine the prognostic value of CSF abnormalities in seropositive autoimmune encephalitis (AE). We retrospectively studied 57 cases of seropositive AE. Primary outcomes were mortality and modified Rankin Scale, while secondary outcomes were first line treatment failure, ICU admission and relapse. Regression analysis was performed. CSF white cell count (WCC) was higher in the NMDAR group, while elevated protein was more common amongst other subtypes. We found an association between WCC >5 cells/mm3 and treatment failure (OR 16.0, p = 0.006)), and between WCC >20 cells/mm3 and ICU admission (OR 19.3, p = 0.026). Different subsets of AE have characteristic CSF abnormalities, which may aid recognition during early evaluation. CSF WCC had prognostic significance in our study. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/25925 | DOI: | 10.1016/j.jneuroim.2021.577508 | Journal: | Journal of Neuroimmunology | PubMed URL: | 33588218 | Type: | Journal Article | Subjects: | Autoimmune encephalitis Biomarker CSF Lymphocytosis Prognosis |
| Appears in Collections: | Journal articles |
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