Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/25748
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dc.contributor.authorDoré, Vincent-
dc.contributor.authorKrishnadas, Natasha-
dc.contributor.authorBourgeat, Pierrick-
dc.contributor.authorHuang, Kun-
dc.contributor.authorLi, Shenpeng-
dc.contributor.authorBurnham, Samantha-
dc.contributor.authorMasters, Colin L-
dc.contributor.authorFripp, Jurgen-
dc.contributor.authorVillemagne, Victor L-
dc.contributor.authorRowe, Christopher C-
dc.date2021-01-26-
dc.date.accessioned2021-02-01T04:24:36Z-
dc.date.available2021-02-01T04:24:36Z-
dc.date.issued2021-07-
dc.identifier.citationEuropean Journal of Nuclear Medicine and Molecular Imaging 2021; 48(7): 2225-2232en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/25748-
dc.description.abstractPrevious studies have shown that Aβ-amyloid (Aβ) likely promotes tau to spread beyond the medial temporal lobe. However, the Aβ levels necessary for tau to spread in the neocortex is still unclear. Four hundred sixty-six participants underwent tau imaging with [18F]MK6420 and Aβ imaging with [18F]NAV4694. Aβ scans were quantified on the Centiloid (CL) scale with a cut-off of 25 CL for abnormal levels of Aβ (A+). Tau scans were quantified in three regions of interest (ROI) (mesial temporal (Me); temporoparietal neocortex (Te); and rest of neocortex (R)) and four mesial temporal region (entorhinal cortex, amygdala, hippocampus, and parahippocampus). Regional tau thresholds were established as the 95%ile of the cognitively unimpaired A- subjects. The prevalence of abnormal tau levels (T+) along the Centiloid continuum was determined. The plots of prevalence of T+ show earlier and greater increase along the Centiloid continuum in the medial temporal area compared to neocortex. Prevalence of T+ was low but associated with Aβ level between 10 and 40 CL reaching 23% in Me, 15% in Te, and 11% in R. Between 40 and 70 CL, the prevalence of T+ subjects per CL increased fourfold faster and at 70 CL was 64% in Me, 51% in Te, and 37% in R. In cognitively unimpaired, there were no T+ in R below 50 CL. The highest prevalence of T+ were found in the entorhinal cortex, reaching 40% at 40 CL and 80% at 60 CL. Outside the entorhinal cortex, abnormal levels of cortical tau on PET are rarely found with Aβ below 40 CL. Above 40 CL prevalence of T+ accelerates in all areas. Moderate Aβ levels are required before abnormal neocortical tau becomes detectable.en
dc.language.isoeng-
dc.subjectAlzheimer’s diseaseen
dc.subjectAβ-amyloid imagingen
dc.subjectNeurodegenerationen
dc.subjectPositron emission tomographyen
dc.subjectTau imagingen
dc.subjectTauopathiesen
dc.titleRelationship between amyloid and tau levels and its impact on tau spreading.en
dc.typeJournal Articleen
dc.identifier.journaltitleEuropean Journal of Nuclear Medicine and Molecular Imagingen
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Medicine, The University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationThe Australian Dementia Network (ADNeT), Melbourne, Australiaen
dc.identifier.affiliationHealth and Biosecurity Flagship, The Australian eHealth Research Centre, Brisbane, Queensland, Australiaen
dc.identifier.affiliationHealth and Biosecurity Flagship, The Australian eHealth Research Centre, Melbourne, Victoria, Australiaen
dc.identifier.affiliationMolecular Imaging and Therapyen
dc.identifier.doi10.1007/s00259-021-05191-9en
dc.type.contentTexten
dc.identifier.orcid0000-0002-8051-0558en
dc.identifier.pubmedid33495928-
local.name.researcherDoré, Vincent
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptMolecular Imaging and Therapy-
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