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Title: | The Women's Healthy Ageing Project: fertile ground for investigation of healthy participants 'at risk' for dementia | Austin Authors: | Szoeke, Cassandra E I;Robertson, Joanne S;Rowe, Christopher C ;Yates, Paul A ;Campbell, Katherine;Masters, Colin L ;Ames, David;Dennerstein, Lorraine;Desmond, Patricia | Affiliation: | Medicine (University of Melbourne) Molecular Imaging and Therapy National Ageing Research Institute, Parkville, Victoria, Australia Department of Psychiatry, Melbourne, Victoria, Australia Department of Radiology, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia |
Issue Date: | Dec-2013 | Publication information: | International Review of Psychiatry 2013; 25(6): 726-737 | Abstract: | Alzheimer's disease neuropathology (amyloid, tauopathies) and brain atrophy are present decades prior to manifestation of clinical symptoms. With the failure of treatment trials it is becoming clearer that the window for prevention and therapeutic intervention is before significant neuronal loss and clinical deterioration of cognition has occurred. Early identification of those at risk of disease and optimizing their management to prevent disease in later life are crucial to delaying disease onset and improving people's quality of life. The Women's Healthy Aging Project (WHAP) is a longitudinal study of over 400 Australian-born women, epidemiologically randomly sampled in 1990. The WHAP aims to identify modifiable mid-life risk factors for the development of late-life cognitive decline, improve the understanding of the pathogenesis of dementia, and target early disease identification utilizing clinical, biomarker and health risk profiles. These aims are fortified by the ability to leverage the considerable database on health, lifestyle and socio-demographics collected prospectively from 1990 to date. This is the first study with a comprehensive neuropsychological battery, over a decade of cognitive follow-up, with all participants being offered amyloid imaging from 2012, and prospective longitudinal data including clinical and physical measures and bio-bank samples from over 20 years prior. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/25733 | DOI: | 10.3109/09540261.2013.873394 | Journal: | International Review of Psychiatry | Type: | Journal Article | Subjects: | Aged Aging Dementia Longitudinal Studies Prodromal Symptoms Prospective Studies Risk Factors |
Appears in Collections: | Journal articles |
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