Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/25387
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DC Field | Value | Language |
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dc.contributor.author | Gandhi, Maher K | - |
dc.contributor.author | Hoang, Thanh | - |
dc.contributor.author | Law, Soi C | - |
dc.contributor.author | Brosda, Sandra | - |
dc.contributor.author | O'Rourke, Kacey | - |
dc.contributor.author | Tobin, Joshua W D | - |
dc.contributor.author | Vari, Frank | - |
dc.contributor.author | Murigneux, Valentine | - |
dc.contributor.author | Fink, J Lynn | - |
dc.contributor.author | Gunawardana, Jay | - |
dc.contributor.author | Gould, Clare M | - |
dc.contributor.author | Oey, Harald | - |
dc.contributor.author | Bednarska, Karolina | - |
dc.contributor.author | Delecluse, Susanne | - |
dc.contributor.author | Trappe, Ralf Ulrich | - |
dc.contributor.author | de Long, Lilia Merida | - |
dc.contributor.author | Sabdia, Muhammed Bilal | - |
dc.contributor.author | Bhagat, Govind | - |
dc.contributor.author | Hapgood, Greg | - |
dc.contributor.author | Blyth, Emily | - |
dc.contributor.author | Clancy, Leighton E | - |
dc.contributor.author | Wight, Joel C | - |
dc.contributor.author | Hawkes, Eliza A | - |
dc.contributor.author | Rimsza, Lisa M | - |
dc.contributor.author | Maguire, Alanna | - |
dc.contributor.author | Bojarczuk, Kamil | - |
dc.contributor.author | Chapuy, Bjoern | - |
dc.contributor.author | Keane, Colm | - |
dc.date | 2020-11-17 | - |
dc.date.accessioned | 2020-11-25T04:54:40Z | - |
dc.date.available | 2020-11-25T04:54:40Z | - |
dc.date.issued | 2020-03-18 | - |
dc.identifier.citation | Blood 2021; 137(11): 1468-1477 | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/25387 | - |
dc.description.abstract | Primary central nervous system lymphoma (PCNSL) is confined to the brain, eyes, and cerebrospinal fluid without evidence of systemic spread. Rarely, PCNSL occurs in the context of immunosuppression, e.g. post-transplant lymphoproliferative disorders (PTLD) or HIV (AIDS-related PCNSL). These cases are poorly characterized, have dismal outcome and are typically Epstein-Barr virus (EBV)-tissue positive. We used targeted sequencing and digital multiplex gene expression to compare the genetic landscape and tumor microenvironment (TME) of 91 PCNSL tissues all with diffuse large B-cell lymphoma histology. 47 were EBV-tissue negative: 45 EBV(-) HIV(-) PCNSL, 2 EBV(-) HIV(+) PCNSL; and 44 were EBV-tissue positive: 23 EBV(+) HIV(+) PCNSL, 21 EBV(+) HIV(-) PCNSL. As with prior studies, EBV(-) HIV(-) PCNSL had frequent MYD88, CD79B and PIM1 mutations, and enrichment for the activated B-cell (ABC) cell-of-origin (COO) sub-type. In contrast, these mutations were absent in all EBV-tissue positive cases and ABC frequency was low. Furthermore, copy number loss in HLA-class I/II and antigen presenting/processing genes were rarely observed, indicating retained antigen presentation. To counter this, EBV(+) HIV(-) PCNSL had a tolerogenic TME with elevated macrophage and immune-checkpoint gene expression, whereas AIDS-related PCNSL had low CD4 gene counts. EBV-tissue positive PCNSL in the immunosuppressed is immunobiologically distinct from EBV(-) HIV(-) PCNSL, and despite expressing an immunogenic virus retains the ability to present EBV-antigens. Results provide a framework for targeted treatment. | en |
dc.language.iso | eng | |
dc.title | EBV-tissue positive primary CNS lymphoma occurring after immunosuppression is a distinct immunobiological entity. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Blood | en |
dc.identifier.affiliation | Haematology, Princess Alexandra Hospital, Australia | en |
dc.identifier.affiliation | Mater Research, Translational Research Institute, Brisbane, Woolloongabba, Australia | en |
dc.identifier.affiliation | Diamantina Institute UQ, Brisbane, Australia | en |
dc.identifier.affiliation | Peter MacCallum Cancer Centre, Melbourne, Australia | en |
dc.identifier.affiliation | The University of Queensland, Brisbane, Australia | en |
dc.identifier.affiliation | University of Queensland, Diamantina Institute, Translational Research Institute, Brisbane, Australia | en |
dc.identifier.affiliation | QIMR, Herston, Australia | en |
dc.identifier.affiliation | University of Queensland, Brisbane, Australia | en |
dc.identifier.affiliation | Mater Research Institute UQ, Brisbane, Australia | en |
dc.identifier.affiliation | University of Medicine and Pharmacy, Hue University, Vietnam.. | en |
dc.identifier.affiliation | Westmead Hospital, Sydney, Australia | en |
dc.identifier.affiliation | Princess Alexandra Hospital, brisbane, Australia | en |
dc.identifier.affiliation | Olivia Newton-John Cancer Research Institute | en |
dc.identifier.affiliation | Sydney Cellular Therapies Laboratory, Westmead, Australia | en |
dc.identifier.affiliation | Princess Alexandra Hospital, Brisbane, Australia | en |
dc.identifier.affiliation | DKFZ, German Cancer Research Centre, Heidelberg, Germany | en |
dc.identifier.affiliation | DIAKO Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany | en |
dc.identifier.affiliation | Columbia University Medical Center, New York, New York, United States | en |
dc.identifier.affiliation | Mayo Clinic, Scottsdale, Arizona, United States | en |
dc.identifier.affiliation | University Medical Center Göttingen, Department of Hematology and Oncology, Göttingen, Germany | en |
dc.identifier.affiliation | University Medical Center Göttingen, Goettingen, Massachusetts, Germany | en |
dc.identifier.doi | 10.1182/blood.2020008520 | en |
dc.type.content | Text | en |
dc.identifier.pubmedid | 33202420 | |
local.name.researcher | Hawkes, Eliza A | |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | Journal Article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Clinical Haematology | - |
crisitem.author.dept | Olivia Newton-John Cancer Wellness and Research Centre | - |
crisitem.author.dept | Clinical Haematology | - |
crisitem.author.dept | Olivia Newton-John Cancer Wellness and Research Centre | - |
crisitem.author.dept | Olivia Newton-John Cancer Research Institute | - |
Appears in Collections: | Journal articles |
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