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https://ahro.austin.org.au/austinjspui/handle/1/25151
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Roberts, Stuart K | - |
dc.contributor.author | Strasser, Simone I | - |
dc.contributor.author | Nicoll, Amanda J | - |
dc.contributor.author | Kemp, William | - |
dc.contributor.author | Majeed, Ammar | - |
dc.contributor.author | Mitchell, Joanne | - |
dc.contributor.author | Stuart, Katherine | - |
dc.contributor.author | Gow, Paul J | - |
dc.contributor.author | Sood, Siddharth | - |
dc.contributor.author | MacQuillan, Gerry | - |
dc.contributor.author | George, Jacob | - |
dc.contributor.author | Mitchell, Jonathan | - |
dc.contributor.author | McCaughan, Geoffrey W | - |
dc.date | 2020-10-17 | - |
dc.date.accessioned | 2020-10-27T03:57:22Z | - |
dc.date.available | 2020-10-27T03:57:22Z | - |
dc.date.issued | 2020-11 | - |
dc.identifier.citation | Scandinavian Journal of Gastroenterology 2020; 55(11): 1309-1317 | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/25151 | - |
dc.description.abstract | As data is limited on the outcomes of calcineurin inhibitors (CNI) in autoimmune hepatitis (AIH), we evaluated the efficacy and safety of CNI in AIH patients who failed prior treatment(s). A retrospective study was performed of AIH patients who received cyclosporine A (CsA) and/or tacrolimus (TAC) after prior treatment(s) failure. Records were reviewed for baseline demographic and clinical characteristics, and treatment outcomes. The primary outcome was biochemical remission. Results: Thirty-three AIH patients received CNI across seven liver centers:17 received CsA, 21 TAC and 5 TAC after CsA failure/intolerance. 82% received CNI for an insufficient response to treatment(s). Overall, 48% of CNI treated patients achieved biochemical remission including 41% in prior non-responders and 83% in treatment intolerant patients. Remission rates with CNI as second-line and third-line therapy were 63% and 29% respectively. There were no baseline predictors of response to CNI on multivariate analysis. Eighteen (55%) patients developed significant side effects and 8 (24%) discontinued due to intolerance. Three patients required liver transplantation for decompensated cirrhosis and 6 patients died including one from malignancy possibly related to CNI. CNI salvage therapy is well tolerated and moderately effective achieving remission in around 50% of AIH who failed standard therapy. | en |
dc.language.iso | eng | |
dc.subject | Tacrolimus | en |
dc.subject | autoimmune hepatitis | en |
dc.subject | cirrhosis | en |
dc.subject | cyclosporine | en |
dc.subject | refractory immunosuppression | en |
dc.subject | remission | en |
dc.subject | response | en |
dc.title | Efficacy and safety profile of calcineurin inhibitor salvage therapy in autoimmune hepatitis. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Scandinavian Journal of Gastroenterology | en |
dc.identifier.affiliation | Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital, Sydney, Australia | en |
dc.identifier.affiliation | Centenary Research Institute, Sydney, Australia | en |
dc.identifier.affiliation | Sunshine Coast General Hospital, Nambour, Australia | en |
dc.identifier.affiliation | The Alfred Hospital, Melbourne, Australia | en |
dc.identifier.affiliation | Monash University, Melbourne, Australia | en |
dc.identifier.affiliation | Eastern Health, Melbourne, Australia | en |
dc.identifier.affiliation | Sir Charles Gairdner Hospital, Perth, Australia | en |
dc.identifier.affiliation | Royal Prince Alfred Hospital, Sydney, Australia | en |
dc.identifier.affiliation | University of Sydney, Sydney, Australia | en |
dc.identifier.affiliation | Royal Melbourne Hospital, Melbourne, Australia | en |
dc.identifier.affiliation | Austin Health | en |
dc.identifier.affiliation | Princess Alexandra Hospital, Brisbane, Australia | en |
dc.identifier.doi | 10.1080/00365521.2020.1821764 | en |
dc.type.content | Text | en |
dc.identifier.pubmedid | 33070650 | |
local.name.researcher | Gow, Paul J | |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairetype | Journal Article | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | Victorian Liver Transplant Unit | - |
crisitem.author.dept | Gastroenterology and Hepatology | - |
crisitem.author.dept | Victorian Liver Transplant Unit | - |
Appears in Collections: | Journal articles |
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