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https://ahro.austin.org.au/austinjspui/handle/1/23584| Title: | Features of intracranial hemorrhage in cerebral venous thrombosis. | Austin Authors: | Afifi, K;Bellanger, G;Buyck, P J;Zuurbier, S M;Esperon, C G;Barboza, M A;Costa, P;Escudero, I;Renard, D;Lemmens, R;Hinteregger, N;Fazekas, F;Conde, J Jimenez;Giralt-Steinhauer, E;Hiltunen, S;Arauz, A;Pezzini, A;Montaner, J;Putaala, J;Weimar, C;Schlamann, Marc;Gattringer, T;Tatlisumak, T;Coutinho, J M;Demaerel, P;Thijs, Vincent N | Affiliation: | Department of Neurology, John Hunter Hospital, University of Newcastle, Newcastle, Australia Department of Clinical Neuroscience/Neurology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden Neurovascular Lab, Instituto de Biomedicina de Sevilla, Sevilla, Spain Universitat Autònoma de Barcelon, Barcelona, Spain Department of Clinical and Experimental Sciences, Neurology Clinic University of Brescia, Brescia, Italy Department of Neurology, Hospital Universitario Virgen Macarena, Seville, Spain.. Department of Neurology, Neurovascular Research Group, IMIM-Hospital del Mar, Barcelona, Spain Universitat Autònoma de Barcelon, Barcelona, Spain Department of Neurosciences, Experimental Neurology and Leuven Institute for Neuroscience and Disease (LIND), KU Leuven-University of Leuven, Leuven, Belgium Laboratory of Neurobiology, Center for Brain and Disease Research, VIB, Leuven, Belgium Department of Neurology, University Hospitals Leuven, Leuven, Belgium Neurology Department, University Hospital Virgen del Rocio, Sevilla, Spain Neurovascular Lab, Instituto de Biomedicina de Sevilla, Sevilla, Spain Department of Neurology, Menoufia University, Al Minufya, Menoufia, Egypt Stroke Division, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Heidelberg, Victoria, Australia Department of Neuroradiology, Purpan University Hospital, Toulouse, France Department of Neurology, Austin Health, Heidelberg, Victoria, Australia Department of Head and Neck, Neurology Clinic, University of Brescia, Brescia, Italy Department of Neurology, Helsinki University Hospital, Helsinki, Finland Department of Radiology, University Hospitals Leuven, Leuven, Belgium Department of Neurology, Amsterdam University Medical Centers, Location Academic Medical Center, Amsterdam, The Netherlands Stroke Department, Instituto Nacional de Neurología Y Neurocirugía Dr. Manuel Velasco Suárez, México City, México Department of Neurology, Nîmes University Hospital, Nîmes, France Department of Radiology, Division of Neuroradiology, Vascular and Interventional Radiology, Medical University of Graz, Graz, Austria Department of Neurology, Medical University of Graz, Graz, Austria Department of Neurology, Helsinki University Hospital, Helsinki, Finland Stroke Department, Instituto Nacional de Neurología Y Neurocirugía Dr. Manuel Velasco Suárez, México City, México Department of Neurology, Helsinki University Hospital, Helsinki, Finland Department of Neurology, University Hospital Essen, Essen, Germany Institute for Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany Department of Radiology, Division of Neuroradiology, Vascular and Interventional Radiology, Medical University of Graz, Graz, Austria.. Department of Neurology, Amsterdam University Medical Centers, Location Academic Medical Center, Amsterdam, The Netherlands Department of Radiology, University Hospitals Leuven, Leuven, Belgium |
Issue Date: | Nov-2020 | Date: | 2020-06-22 | Publication information: | Journal of Neurology 2020; 267(11): 3292-3298 | Abstract: | Cerebral venous thrombosis (CVT) is associated with intracranial hemorrhage. To identify clinical and imaging features of CVT-associated intracranial hemorrhage. We hypothesized that higher clot burden would be associated with a higher risk of intracranial hemorrhage. We performed a retrospective analysis of an international, multicenter cohort of patients with confirmed cerebral venous thrombosis who underwent computed tomography within 2 weeks of symptom onset. Clinical and imaging features were compared between patients with and without intracranial hemorrhage. Clot burden was assessed by counting the number of thrombosed venous sinuses and veins on confirmatory imaging. We enrolled 260 patients from 10 institutions in Europe and Mexico. The mean age was 42 years and 74% were female. Intracranial hemorrhage was found in 102 (39%). Among them parenchymal hemorrhage occurred in 64 (63%), in addition, small juxta-cortical hemorrhage was found in 30 (29%), subarachnoid hemorrhage in 24 (24%) and subdural hemorrhage in 11 (11%). Multiple concomitant types of hemorrhage occurred in 23 (23%). Older age and superior sagittal thrombosis involvement were associated with presence of hemorrhage. The number of thrombosed venous sinuses was not associated with intracranial hemorrhage (median number IQRInterquartile ratio] of sinuses/veins involved with hemorrhage 2 (1-3) vs. 2 (1-3) without hemorrhage, p = 0.4). The high rate of intracranial hemorrhage in cerebral venous thrombosis is not explained by widespread involvement of the venous sinuses. Superior sagittal sinus involvement is associated with higher bleeding risk. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/23584 | DOI: | 10.1007/s00415-020-10008-0 | ORCID: | 0000-0002-6767-2464 0000-0002-6614-8417 |
Journal: | Journal of Neurology | PubMed URL: | 32572620 | Type: | Journal Article | Subjects: | Bleeding. Cerebral venous thrombosis Hemorrhage Stroke |
| Appears in Collections: | Journal articles |
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