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https://ahro.austin.org.au/austinjspui/handle/1/22761| Title: | Three-step two-pot automated production of NCA [18F]FDOPA with FlexLab module. | Austin Authors: | Huang, Ya-Yao;Poniger, Stan ;Tsai, Chia-Ling;Tochon-Danguy, Henri J ;Ackermann, Uwe ;Yen, Ruoh-Fang | Affiliation: | PET Center, Department of Nuclear Medicine, National Taiwan University Hospital, 7, Chung-Shan S. Road, Taipei, 100, Taiwan. iPHASE Technologies, 3 Cypress Ave, Glen Waverley, Victoria, 3150, Australia PET Center, Department of Nuclear Medicine, National Taiwan University Hospital, 7, Chung-Shan S. Road, Taipei, 100, Taiwan Molecular Imaging Center, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, 106, Taiwan Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, Victoria, Australia PET Center, Department of Nuclear Medicine, National Taiwan University Hospital, 7, Chung-Shan S. Road, Taipei, 100, Taiwan |
Issue Date: | 22-Aug-2019 | Date: | 2019-08-22 | Publication information: | Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2019; online first: 22 August | Abstract: | Automated three-step two-pot production of no-carrier-added (NCA) [18F]FDOPA was first implemented in the iPHASE FlexLab module. Decay-corrected radiochemical yield (RCY) of [18F]FDOPA synthesized by this method was 10~14% (n = 7) with a synthesis time of ~110 min [18F]FDOPA was obtained in > 95% of radiochemical purity with a molar activity of ~431 GBq/μmol. With the method successfully implementing on the commercial FlexLab module and its built-in step-by-step activity monitoring, further processes optimization would be achieved. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/22761 | DOI: | 10.1016/j.apradiso.2019.108871 | Journal: | Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine | PubMed URL: | 32113705 | Type: | Journal Article | Subjects: | Automated production PET imaging [(18)F]FDOPA iPHASE FlexLab module |
| Appears in Collections: | Journal articles |
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