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https://ahro.austin.org.au/austinjspui/handle/1/22335| Title: | Hourly Fluid Balance in Patients Receiving Continuous Renal Replacement Therapy. | Austin Authors: | Naorungroj, Thummaporn ;Serpa Neto, Ary ;Zwakman-Hessels, Lara;Yanase, Fumitaka ;Eastwood, Glenn M ;Bellomo, Rinaldo | Affiliation: | Australian and New Zealand Intensive Care Research Center, Monash University School of Public Health and Preventive Medicine, Melbourne, Victoria, Australia Department of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil Department of Intensive Care Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands Department of Intensive Care Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand Intensive Care Department of Critical Care Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Centre for Integrated Critical Care, The University of Melbourne, Melbourne, Victoria, Australia Data Analytics Research and Evaluation (DARE) Centre, Austin Health and The University of Melbourne, Heidelberg, Victoria, Australia |
Issue Date: | 2020 | Date: | 2019-12-17 | Publication information: | Blood Purification 2020; 49(1-2): 93-101 | Abstract: | Little is known about early (first 48 h) hourly and cumulative fluid balance (FB) during continuous renal replacement therapy (CRRT). To study the characteristics and outcome associations of early hourly and cumulative FB. We studied FB in CRRT patients (2016-2018). Among 350 patients, mean hourly FB became negative after 20 CRRT hours, but within 6 CRRT hours in patients with baseline fluid overload. A negative early FB was never achieved in patients receiving vasopressor therapy (p < 0.001). Mortality was 31%. The percentage of hourly negative FB was independently associated with decreased ICU mortality. A time-weighted hourly FB between 18.5 and -33 mL/h was also significantly and independently associated with decreased mortality. In CRRT patients, an early FB conservative approach is possible, modulated by patient characteristics, and associated with a low mortality. Moreover, avoidance of an early positive FB is associated with decreased mortality. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/22335 | DOI: | 10.1159/000503771 | ORCID: | 0000-0002-1650-8939 | Journal: | Blood Purification | PubMed URL: | 31846982 | Type: | Journal Article | Subjects: | Continuous renal replacement therapy Fluid overload Hourly fluid balance Mortality Vasopressors |
| Appears in Collections: | Journal articles |
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