1. AHRO : Austin Health Research Online
  2. Austin Health research
  3. Journal articles
Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/22183
Full metadata record
DC FieldValueLanguage
dc.contributor.authorVacher, Michael-
dc.contributor.authorPorter, Tenielle-
dc.contributor.authorVillemagne, Victor L-
dc.contributor.authorMilicic, Lidija-
dc.contributor.authorPeretti, Madeline-
dc.contributor.authorFowler, Christopher-
dc.contributor.authorMartins, Ralph-
dc.contributor.authorRainey-Smith, Stephanie-
dc.contributor.authorAmes, David-
dc.contributor.authorMasters, Colin L-
dc.contributor.authorRowe, Christopher C-
dc.contributor.authorDoecke, James D-
dc.contributor.authorLaws, Simon M-
dc.date2019-11-19-
dc.date.accessioned2019-12-04T04:59:39Z-
dc.date.available2019-12-04T04:59:39Z-
dc.date.issued2019-11-19-
dc.identifier.citationScientific Reports 2019; 9(1): 17069en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/22183-
dc.description.abstractThe accumulation of brain amyloid β (Aβ) is one of the main pathological hallmarks of Alzheimer's disease (AD). However, the role of brain amyloid deposition in the development of AD and the genetic variants associated with this process remain unclear. In this study, we sought to identify associations between Aβ deposition and an a priori evidence based set of 1610 genetic markers, genotyped from 505 unrelated individuals (258 Aβ+ and 247 Aβ-) enrolled in the Australian Imaging, Biomarker & Lifestyle (AIBL) study. We found statistically significant associations for 6 markers located within intronic regions of 6 genes, including AC103796.1-BDNF, PPP3R1, NGFR, KL, ABCA7 & CALHM1. Although functional studies are required to elucidate the role of these genes in the accumulation of Aβ and their potential implication in AD pathophysiology, our findings are consistent with results obtained in previous GWAS efforts.en
dc.language.isoeng-
dc.titleValidation of a priori candidate Alzheimer's disease SNPs with brain amyloid-beta deposition.en
dc.typeJournal Articleen
dc.identifier.journaltitleScientific Reportsen
dc.identifier.affiliationCSIRO Health and Biosecurity, Australian e-Health Research Centre, Floreat, 6014, Western Australia, Australiaen
dc.identifier.affiliationCollaborative Genomics Group, Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, 6027, Western Australia, Australiaen
dc.identifier.affiliationCooperative Research Centre for Mental Health, Carlton South, 3053, Victoria, Australiaen
dc.identifier.affiliationDepartment of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, 3084, Victoria, Australiaen
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, 3052, Victoria, Australiaen
dc.identifier.affiliationDepartment of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationCollaborative Genomics Group, Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, 6027, Western Australia, Australiaen
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, 3052, Victoria, Australiaen
dc.identifier.affiliationCentre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, 6027, Western Australia, Australiaen
dc.identifier.affiliationNational Ageing Research Institute, Parkville, 3052, Victoria, Australiaen
dc.identifier.affiliationDepartment of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationCSIRO Health and Biosecurity, Australian e-Health Research Centre, Herston, 4029, Queensland, Australiaen
dc.identifier.affiliationSchool of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, 6102, Western Australia, Australiaen
dc.identifier.doi10.1038/s41598-019-53604-5en
dc.type.contentTexten
dc.identifier.orcid0000-0002-7887-6622en
dc.identifier.orcid0000-0003-0375-8370en
dc.identifier.orcid0000-0002-5832-9875en
dc.identifier.orcid0000-0002-4355-7082en
dc.identifier.orcid0000-0003-3910-2453en
dc.identifier.orcid0000-0003-2863-0293en
dc.identifier.pubmedid31745181-
dc.type.austinJournal Article-
local.name.researcherMasters, Colin L
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.grantfulltextnone-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptMolecular Imaging and Therapy-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

60
checked on Feb 11, 2025

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.