Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/21960
Title: | Genioglossus muscle responses to resistive loads in severe OSA patients and healthy controls. | Austin Authors: | Ruehland, Warren R ;Rochford, Peter D ;Pierce, Robert J ;Trinder, John A;Jordan, Amy S ;Cori, Jennifer M ;O'Donoghue, Fergal J | Affiliation: | Respiratory and Sleep Medicine Sleep Laboratory, Melbourne School of Psychological Sciences, University of Melbourne, Australia Melbourne School of Psychological Sciences, University of Melbourne, Australia Institute for Breathing and Sleep, Austin Health, Australia Institute for Breathing and Sleep |
Issue Date: | 1-Dec-2019 | Date: | 2019-10-24 | Publication information: | Journal of Applied Physiology 2019; 127(6): 1586-1598 | Abstract: | This study aimed to determine whether there was impairment of genioglossus neuromuscular responses to small negative pressure respiratory stimuli, close to the conscious detection threshold, in obstructive sleep apnea (OSA). We compared genioglossus electromyogram (EMGgg) responses to mid-inspiratory resistive loads of varying intensity (≈1.2 to 6.2 cmH2O·L‑1·s), delivered via a nasal mask, between 16 severe OSA and 17 control participants while the subjects were awake and in a seated upright position. We examined the relationship between stimulus intensity and peak EMGgg amplitude in a 200ms post-stimulus window, and hypothesized that OSA patients would have an increased activation threshold and reduced sensitivity in the relationship between EMGgg activation and stimulus intensity. There was no significant difference between control and OSA participants in the threshold (P = 0.545) or the sensitivity (P = 0.482) of the EMGgg amplitude vs. stimulus intensity relationship, where change in epiglottic pressure relative to background epiglottic pressure represented stimulus intensity. These results do not support the hypothesis that deficits in neuromuscular response to negative upper airway pressure exist in OSA during wakefulness, however the results are likely influenced by a counterintuitive and novel genioglossus muscle suppression response observed in a significant proportion of both OSA and healthy control participants. This suppression response may relate to the inhibition seen in inspiratory muscles such as the diaphragm in response to sudden onset negative pressure, and its presence provides new insight into the upper airway neuromuscular response to the collapsing force of negative pressure. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/21960 | DOI: | 10.1152/japplphysiol.00186.2019 | ORCID: | 0000-0001-9626-7460 0000-0001-5099-3184 |
Journal: | Journal of Applied Physiology | PubMed URL: | 31647723 | Type: | Journal Article | Subjects: | Genioglossus Negative pressure reflex Neuromuscular response Obstructive sleep apnea Resistive load |
Appears in Collections: | Journal articles |
Show full item record
Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.